Autophagy Mediates Tumor Suppression via Cellular Senescence

Lorenzo Galluzzi; José Manuel Bravo-San Pedro; Guido Kroemer

doi:10.1016/j.tcb.2015.11.001

Autophagy Mediates Tumor Suppression via Cellular Senescence

Lorenzo Galluzzi
, José Manuel Bravo-San Pedro
, Guido Kroemer

Research output: Contribution to journal › Short survey › peer-review

38 Scopus citations

Abstract

Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Trends in Cell Biology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.tcb.2015.11.001
State	Published - Jan 1 2016
Externally published	Yes

Keywords

ATG7
Cytoplasmic chromatin fragments
HRAS
LC3
Lamin B1
Tumor suppression

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10.1016/j.tcb.2015.11.001

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title = "Autophagy Mediates Tumor Suppression via Cellular Senescence",

abstract = "Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.",

keywords = "ATG7, Cytoplasmic chromatin fragments, HRAS, LC3, Lamin B1, Tumor suppression",

author = "Lorenzo Galluzzi and \{Bravo-San Pedro\}, \{Jos{\'e} Manuel\} and Guido Kroemer",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2016",

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doi = "10.1016/j.tcb.2015.11.001",

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T1 - Autophagy Mediates Tumor Suppression via Cellular Senescence

AU - Galluzzi, Lorenzo

AU - Bravo-San Pedro, José Manuel

AU - Kroemer, Guido

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.

AB - Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.

KW - ATG7

KW - Cytoplasmic chromatin fragments

KW - HRAS

KW - LC3

KW - Lamin B1

KW - Tumor suppression

UR - https://www.scopus.com/pages/publications/84955323618

U2 - 10.1016/j.tcb.2015.11.001

DO - 10.1016/j.tcb.2015.11.001

M3 - Short survey

C2 - 26612212

AN - SCOPUS:84955323618

SN - 0962-8924

VL - 26

SP - 1

EP - 3

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 1

ER -

Autophagy Mediates Tumor Suppression via Cellular Senescence

Abstract

Keywords

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