Autophagy Mediates Tumor Suppression via Cellular Senescence

Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Guido Kroemer

Research output: Contribution to journalShort surveypeer-review

37 Scopus citations

Abstract

Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalTrends in Cell Biology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • ATG7
  • Cytoplasmic chromatin fragments
  • HRAS
  • Lamin B1
  • LC3
  • Tumor suppression

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