Abstract
Autophagy not only constitutes a robust barrier against malignant transformation at the cell-intrinsic level, but also contributes to the organismal control of potentially oncogenic cells. Recent data provide molecular insights into the mechanisms whereby oncogene hyperactivation induces autophagy to establish a permanent proliferative arrest commonly known as cellular senescence.
Original language | English |
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Pages (from-to) | 1-3 |
Number of pages | 3 |
Journal | Trends in Cell Biology |
Volume | 26 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2016 |
Externally published | Yes |
Keywords
- ATG7
- Cytoplasmic chromatin fragments
- HRAS
- Lamin B1
- LC3
- Tumor suppression