Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors

Guido Kroemer; Lorenzo Galluzzi

doi:10.18632/oncotarget.13892

Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors

Guido Kroemer, Lorenzo Galluzzi

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Recent data suggest that autophagy does not influence spontaneous and therapy-elicited tumor infiltration by immune cells in murine models of melanoma and breast carcinoma. These findings, which have been obtained in the absence of a therapeutically relevant anticancer immune response, indicate that the intrinsically low immunogenicity of some tumors cannot be compensated for by increased danger signaling.

Original language	English
Pages (from-to)	5686-5691
Number of pages	6
Journal	Oncotarget
Volume	8
Issue number	4
DOIs	https://doi.org/10.18632/oncotarget.13892
State	Published - 2017
Externally published	Yes

Keywords

ATP
Chloroquine
Damage-associated molecular patterns
Doxorubicin
Immunogenic cell death
Radiation therapy

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10.18632/oncotarget.13892

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abstract = "Recent data suggest that autophagy does not influence spontaneous and therapy-elicited tumor infiltration by immune cells in murine models of melanoma and breast carcinoma. These findings, which have been obtained in the absence of a therapeutically relevant anticancer immune response, indicate that the intrinsically low immunogenicity of some tumors cannot be compensated for by increased danger signaling.",

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AU - Galluzzi, Lorenzo

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AB - Recent data suggest that autophagy does not influence spontaneous and therapy-elicited tumor infiltration by immune cells in murine models of melanoma and breast carcinoma. These findings, which have been obtained in the absence of a therapeutically relevant anticancer immune response, indicate that the intrinsically low immunogenicity of some tumors cannot be compensated for by increased danger signaling.

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KW - Chloroquine

KW - Damage-associated molecular patterns

KW - Doxorubicin

KW - Immunogenic cell death

KW - Radiation therapy

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Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors

Abstract

Keywords

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