Abstract
Autophagy is a key mechanism for the maintenance of intracellular and organismal homeostasis. Accordingly, defects in core components of the autophagic machinery are etiologically associated with a variety of human pathologies, including infectious disorders, cardiovascular diseases, neurodegenerative conditions, and cancer. Intriguingly, several maneuvers that increase the lifespan of model organisms in the laboratory, like caloric restriction, do so in an autophagy-dependent manner. Here, we briefly discuss the intimate relationship between the autophagic preservation of intracellular and organismal fitness and healthy aging.
| Translated title of the contribution | Autophagy, fitness and longevity |
|---|---|
| Original language | French |
| Pages (from-to) | 246-251 |
| Number of pages | 6 |
| Journal | Medecine/Sciences |
| Volume | 33 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2017 |
| Externally published | Yes |
