TY - JOUR
T1 - Atypical retinal astrocytic hamartoma diagnosed by fine-needle biopsy
AU - Shields, J. A.
AU - Shields, C. L.
AU - Ehya, H.
AU - Buckley, E.
AU - De Potter, P.
PY - 1996
Y1 - 1996
N2 - Background: Retinal astrocytic hamartoma and retinoblastoma may be very similar clinically, and their differentiation in atypical cases can be difficult, even with the use of ancillary methods such as fluorescein angiography, ultrasonography, and computed tomography. To the authors' knowledge, fine-needle aspiration biopsy has not been used to diagnose astrocytic hamartoma in such cases. Patients and Methods: A 7-week-old boy had a minimally calcified retinal mass in the macular area of the left eye associated with an extensive secondary retinal detachment. The differential diagnosis included retinal astrocytic hamartoma and retinoblastoma. A transvitreal fine-needle aspiration biopsy was performed. Results: The cytology of the needle biopsy showed benign spindle and stellate cells, which were compatible with glial cells. The lesion had immunoreactivity for glial fibrillary acidic protein, further supporting the diagnosis of astrocytic tumor. Conclusion: Fine-needle aspiration biopsy is diagnostically useful in unusual cases where the differential diagnosis between retinoblastoma and astrocytic hamartoma is difficult.
AB - Background: Retinal astrocytic hamartoma and retinoblastoma may be very similar clinically, and their differentiation in atypical cases can be difficult, even with the use of ancillary methods such as fluorescein angiography, ultrasonography, and computed tomography. To the authors' knowledge, fine-needle aspiration biopsy has not been used to diagnose astrocytic hamartoma in such cases. Patients and Methods: A 7-week-old boy had a minimally calcified retinal mass in the macular area of the left eye associated with an extensive secondary retinal detachment. The differential diagnosis included retinal astrocytic hamartoma and retinoblastoma. A transvitreal fine-needle aspiration biopsy was performed. Results: The cytology of the needle biopsy showed benign spindle and stellate cells, which were compatible with glial cells. The lesion had immunoreactivity for glial fibrillary acidic protein, further supporting the diagnosis of astrocytic tumor. Conclusion: Fine-needle aspiration biopsy is diagnostically useful in unusual cases where the differential diagnosis between retinoblastoma and astrocytic hamartoma is difficult.
KW - Astrocytes/pathology
KW - Biopsy, Needle
KW - Diagnosis, Differential
KW - Eye Abnormalities/complications
KW - Eye Neoplasms/diagnosis
KW - Fluorescein Angiography
KW - Fundus Oculi
KW - Hamartoma/complications
KW - Humans
KW - Infant
KW - Male
KW - Retina/abnormalities
KW - Retinal Detachment/etiology
KW - Retinoblastoma/diagnosis
UR - http://www.scopus.com/inward/record.url?scp=0029982540&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1996UR71300026&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/S0161-6420(96)30581-2
DO - 10.1016/S0161-6420(96)30581-2
M3 - Article
C2 - 8643253
SN - 0161-6420
VL - 103
SP - 949
EP - 952
JO - Ophthalmology
JF - Ophthalmology
IS - 6
ER -