Atypical cysts and carcinomas of the kidneys in the phacomatoses. A quantitative dna study using static and flow cytometry

Roberto E. Ibrahim, David S. Weinberg, Noel Weidner

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Reported are the pathologic features of atypical cysts and/or renal cell carcinomas found in the kidneys of four patients having either tuberous sclerosis or Hippel‐Lindau disease. In addition, cellular DNA contents of the cells lining the atypical cysts and comprising the carcinomas were quantitated using both static and flow cytometric techniques. These studies showed that cysts lined by atypical epithelial cells are frequently present in renal parenchyma adjacent to the renal carcinomas, and that the cytologic features of atypical cells lining the cysts were essentially the same as the cytologic features found in the adjacent well‐differentiated, renal cell carcinomas. DNA quantitative studies revealed that both the renal cell carcinomas and the atypical cyst lining cells had the same DNA indices and were essentially DNA euploid. In this patient group these findings are consistent with the hypothesis that the atypical cyst lining cells evolve into the renal cell carcinomas; however, they do not prove this proposed but likely sequence.

Original languageEnglish
Pages (from-to)148-157
Number of pages10
JournalCancer
Volume63
Issue number1
DOIs
StatePublished - Jan 1 1989

Keywords

  • Adolescent
  • Adult
  • Angiomatosis/pathology
  • DNA, Neoplasm/analysis
  • Epithelium/ultrastructure
  • Female
  • Flow Cytometry
  • Humans
  • Kidney Diseases, Cystic/analysis
  • Kidney Neoplasms/analysis
  • Male
  • Organelles/ultrastructure
  • Tuberous Sclerosis/pathology
  • von Hippel-Lindau Disease/analysis

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