ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

Yuting Ma; Sandy Adjemian; Heng Yang; João Paulo Portela Catani; Dalil Hannani; Isabelle Martins; Mickaël Michaud; Oliver Kepp; Abdul Qader Sukkurwala; Erika Vacchelli; Lorenzo Galluzzi; Laurence Zitvogel; Guido Kroemer

doi:10.4161/onci.24568

ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

Yuting Ma, Sandy Adjemian, Heng Yang, João Paulo Portela Catani, Dalil Hannani, Isabelle Martins, Mickaël Michaud, Oliver Kepp, Abdul Qader Sukkurwala, Erika Vacchelli, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Tumor cells succumb to chemotherapy while releasing ATP. We have found that extracellular ATP attracts dendritic cell (DC) precursors into the tumor bed, facilitates their permanence in the proximity of dying cells and promotes their differentiation into mature DCs endowed with the capacity of presenting tumor-associated antigens.

Original language	English
Article number	e24568
Journal	Oncoimmunology
Volume	2
Issue number	6
DOIs	https://doi.org/10.4161/onci.24568
State	Published - Jun 2013
Externally published	Yes

Keywords

Apoptosis
Autophagy
CD39
Calreticulin
Doxorubicin
Immunogenic cell death

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Ma, Y., Adjemian, S., Yang, H., Catani, J. P. P., Hannani, D., Martins, I., Michaud, M., Kepp, O., Sukkurwala, A. Q., Vacchelli, E., Galluzzi, L., Zitvogel, L., & Kroemer, G. (2013). ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy. Oncoimmunology, 2(6), Article e24568. https://doi.org/10.4161/onci.24568

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keywords = "Apoptosis, Autophagy, CD39, Calreticulin, Doxorubicin, Immunogenic cell death",

author = "Yuting Ma and Sandy Adjemian and Heng Yang and Catani, {Jo{\~a}o Paulo Portela} and Dalil Hannani and Isabelle Martins and Micka{\"e}l Michaud and Oliver Kepp and Sukkurwala, {Abdul Qader} and Erika Vacchelli and Lorenzo Galluzzi and Laurence Zitvogel and Guido Kroemer",

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AU - Hannani, Dalil

AU - Martins, Isabelle

AU - Michaud, Mickaël

AU - Kepp, Oliver

AU - Sukkurwala, Abdul Qader

AU - Vacchelli, Erika

AU - Galluzzi, Lorenzo

AU - Zitvogel, Laurence

AU - Kroemer, Guido

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KW - Autophagy

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KW - Doxorubicin

KW - Immunogenic cell death

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ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

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Keywords

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