Abstract
Background: Men with familial prostate cancer and African American men are at risk for developing prostate cancer at younger ages. Genetic markers predicting early-onset prostate cancer may provide clinically useful information to guide screening strategies for high-risk men. We evaluated clinical information from six polymorphisms associated with early-onset prostate cancer in a longitudinal cohort of high-risk men enrolled in prostate cancer early detection with significant African American participation. Methods: Eligibility criteria include ages 35 to 69 with a family history of prostate cancer or African American race. Participants undergo screening and biopsy per study criteria. Six markers associated with early-onset prostate cancer [rs2171492 (7q32), rs6983561 (8q24), rs10993994 (10q11), rs4430796 (17q12), rs1799950 (17q21), and rs266849 (19q13)] were genotyped. Cox models were used to evaluate time to prostate cancer diagnosis and prostate-specific antigen (PSA) prediction for prostate cancer by genotype. Harrell's concordance index was used to evaluate predictive accuracy for prostate cancer by PSA and genetic markers. Results: Four hundred and sixty participants with complete data and ≥1 follow-up visit were included. Fifty-six percent were African American. Among African American men, rs6983561 genotype was significantly associated with earlier time to prostate cancer diagnosis (P = 0.005) and influenced prediction for prostate cancer by the PSA (P < 0.001). When combined with PSA, rs6983561 improved predictive accuracy for prostate cancer compared with PSA alone among African American men (PSA = 0.57 vs. PSA + rs6983561 = 0.75, P = 0.03). Conclusions: Early-onset marker rs6983561 adds potentially useful clinical information for African American men undergoing prostate cancer risk assessment. Further study is warranted to validate these findings. Impact: Genetic markers of early-onset prostate cancer have potential to refine and personalize prostate cancer early detection for high-risk men.
Original language | English |
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Pages (from-to) | 53-60 |
Number of pages | 8 |
Journal | Cancer Epidemiology Biomarkers and Prevention |
Volume | 21 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2012 |
Keywords
- Adult
- Aged
- Biomarkers, Tumor/genetics
- Biopsy
- Black or African American
- Cohort Studies
- Early Detection of Cancer/methods
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Prostate-Specific Antigen/genetics
- Prostatic Neoplasms/diagnosis
- Risk Factors