Apoptotic caspases cut down the immunogenicity of radiation

Aitziber Buqué; Maria Esperanza Rodriguez-Ruiz; Jitka Fucikova; Lorenzo Galluzzi

doi:10.1080/2162402X.2019.1655364

Apoptotic caspases cut down the immunogenicity of radiation

Aitziber Buqué, Maria Esperanza Rodriguez-Ruiz, Jitka Fucikova, Lorenzo Galluzzi

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26 Scopus citations

Abstract

Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon secretion. Thus, caspase inhibitors stand out as promising combinatorial partners to improve the immunogenicity of radiation therapy in the clinic.

Original language	English
Article number	e1655364
Journal	Oncoimmunology
Volume	8
Issue number	11
DOIs	https://doi.org/10.1080/2162402X.2019.1655364
State	Published - Nov 2 2019
Externally published	Yes

Keywords

CASP3
CGAS
PGE
SLC7A2
immune checkpoint blockers
mitochondrial outer membrane permeabilization

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10.1080/2162402X.2019.1655364

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abstract = "Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon secretion. Thus, caspase inhibitors stand out as promising combinatorial partners to improve the immunogenicity of radiation therapy in the clinic.",

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AU - Galluzzi, Lorenzo

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Apoptotic caspases cut down the immunogenicity of radiation

Abstract

Keywords

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