Antisense oligonucleotides

Bruno Calabretta, Thomas Skorski, Gerald Zon

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene expression is associated with a selective or a preferential inhibition of tumour as compared to normal cell proliferation. Even though numerous studies attest the short-term in vitro efficacy of antisense oligodeoxynucleotides as inhibitors of tumour growth, the use of these compounds as therapeutic agents awaits a more rigorous demonstration of their long term effects and favourable pharmacological properties.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalSeminars in Cancer Biology
Volume3
Issue number6
StatePublished - Dec 1992

Keywords

  • Antineoplastic Agents/pharmacology
  • Humans
  • Oligonucleotides, Antisense/pharmacology
  • Oncogenes/drug effects

Fingerprint

Dive into the research topics of 'Antisense oligonucleotides'. Together they form a unique fingerprint.

Cite this