Anticipatory Immune Suppression and Nausea in Women Receiving Cyclic Chemotherapy for Ovarian Cancer

Dana H. Bovbjerg; William H. Redd; Lisa A. Maier; Jimmie C. Holland; Lynna M. Lesko; Donna Niedzwiecki; Stephen C. Rubin; Thomas B. Hakes

doi:10.1037/0022-006X.58.2.153

Anticipatory Immune Suppression and Nausea in Women Receiving Cyclic Chemotherapy for Ovarian Cancer

Dana H. Bovbjerg, William H. Redd, Lisa A. Maier, Jimmie C. Holland, Lynna M. Lesko, Donna Niedzwiecki, Stephen C. Rubin, Thomas B. Hakes

Surgery

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Nausea and immune function were assessed in 20 cancer patients in the hospital prior to chemotherapy and compared with assessments conducted at home. Proliferative responses to T-cell mitogens were lower for cells isolated from hospital blood samples than for home samples obtained several days earlier. Patients also experienced increased nausea in the hospital. Hierarchical multiple regression analyses indicated that decreased immune function in the hospital was not related to increased anxiety. The observed anticipatory immune suppression is consistent with the hypothesis that chemotherapy patients may develop conditioned immune suppression as well as conditioned nausea after repeated pairings of hospital stimuli with the emetic and immunosuppressive effects of chemotherapy.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	Journal of Consulting and Clinical Psychology
Volume	58
Issue number	2
DOIs	https://doi.org/10.1037/0022-006X.58.2.153
State	Published - Apr 1990

Keywords

Adult
Aged
Antineoplastic Combined Chemotherapy Protocols/adverse effects
Cisplatin/adverse effects
Cyclophosphamide/adverse effects
Doxorubicin/adverse effects
Female
Humans
Immune Tolerance/drug effects
Leukocyte Count/drug effects
Lymphocyte Activation/drug effects
Middle Aged
Ovarian Neoplasms/drug therapy
Vomiting, Anticipatory/immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1037/0022-006X.58.2.153

Cite this

@article{4944731f66e54ffea6a2cae5da7d4163,

title = "Anticipatory Immune Suppression and Nausea in Women Receiving Cyclic Chemotherapy for Ovarian Cancer",

abstract = "Nausea and immune function were assessed in 20 cancer patients in the hospital prior to chemotherapy and compared with assessments conducted at home. Proliferative responses to T-cell mitogens were lower for cells isolated from hospital blood samples than for home samples obtained several days earlier. Patients also experienced increased nausea in the hospital. Hierarchical multiple regression analyses indicated that decreased immune function in the hospital was not related to increased anxiety. The observed anticipatory immune suppression is consistent with the hypothesis that chemotherapy patients may develop conditioned immune suppression as well as conditioned nausea after repeated pairings of hospital stimuli with the emetic and immunosuppressive effects of chemotherapy.",

keywords = "Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Cisplatin/adverse effects, Cyclophosphamide/adverse effects, Doxorubicin/adverse effects, Female, Humans, Immune Tolerance/drug effects, Leukocyte Count/drug effects, Lymphocyte Activation/drug effects, Middle Aged, Ovarian Neoplasms/drug therapy, Vomiting, Anticipatory/immunology",

author = "Bovbjerg, \{Dana H.\} and Redd, \{William H.\} and Maier, \{Lisa A.\} and Holland, \{Jimmie C.\} and Lesko, \{Lynna M.\} and Donna Niedzwiecki and Rubin, \{Stephen C.\} and Hakes, \{Thomas B.\}",

year = "1990",

month = apr,

doi = "10.1037/0022-006X.58.2.153",

language = "English",

volume = "58",

pages = "153--157",

journal = "Journal of Consulting and Clinical Psychology",

issn = "0022-006X",

publisher = "American Psychological Association",

number = "2",

}

TY - JOUR

T1 - Anticipatory Immune Suppression and Nausea in Women Receiving Cyclic Chemotherapy for Ovarian Cancer

AU - Bovbjerg, Dana H.

AU - Redd, William H.

AU - Maier, Lisa A.

AU - Holland, Jimmie C.

AU - Lesko, Lynna M.

AU - Niedzwiecki, Donna

AU - Rubin, Stephen C.

AU - Hakes, Thomas B.

PY - 1990/4

Y1 - 1990/4

N2 - Nausea and immune function were assessed in 20 cancer patients in the hospital prior to chemotherapy and compared with assessments conducted at home. Proliferative responses to T-cell mitogens were lower for cells isolated from hospital blood samples than for home samples obtained several days earlier. Patients also experienced increased nausea in the hospital. Hierarchical multiple regression analyses indicated that decreased immune function in the hospital was not related to increased anxiety. The observed anticipatory immune suppression is consistent with the hypothesis that chemotherapy patients may develop conditioned immune suppression as well as conditioned nausea after repeated pairings of hospital stimuli with the emetic and immunosuppressive effects of chemotherapy.

AB - Nausea and immune function were assessed in 20 cancer patients in the hospital prior to chemotherapy and compared with assessments conducted at home. Proliferative responses to T-cell mitogens were lower for cells isolated from hospital blood samples than for home samples obtained several days earlier. Patients also experienced increased nausea in the hospital. Hierarchical multiple regression analyses indicated that decreased immune function in the hospital was not related to increased anxiety. The observed anticipatory immune suppression is consistent with the hypothesis that chemotherapy patients may develop conditioned immune suppression as well as conditioned nausea after repeated pairings of hospital stimuli with the emetic and immunosuppressive effects of chemotherapy.

KW - Adult

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols/adverse effects

KW - Cisplatin/adverse effects

KW - Cyclophosphamide/adverse effects

KW - Doxorubicin/adverse effects

KW - Female

KW - Humans

KW - Immune Tolerance/drug effects

KW - Leukocyte Count/drug effects

KW - Lymphocyte Activation/drug effects

KW - Middle Aged

KW - Ovarian Neoplasms/drug therapy

KW - Vomiting, Anticipatory/immunology

UR - https://www.scopus.com/pages/publications/0025026091

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1990CY68400002&DestLinkType=FullRecord&DestApp=WOS

U2 - 10.1037/0022-006X.58.2.153

DO - 10.1037/0022-006X.58.2.153

M3 - Article

C2 - 2335631

SN - 0022-006X

VL - 58

SP - 153

EP - 157

JO - Journal of Consulting and Clinical Psychology

JF - Journal of Consulting and Clinical Psychology

IS - 2

ER -

Anticipatory Immune Suppression and Nausea in Women Receiving Cyclic Chemotherapy for Ovarian Cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this