An IR navigation system for real-time treatment guidance of pleural PDT

Timothy C. Zhu; Xing Liang; Chang Chang; Julia Sandell; Jarod C. Finlay; Andreea Dimofte; Carmen Rodriguez; Keith Cengel; Eli Glatstein; Joseph Friedberg; Stephen M. Hahn

doi:10.1117/12.875635

An IR navigation system for real-time treatment guidance of pleural PDT

Timothy C. Zhu, Xing Liang, Chang Chang, Julia Sandell, Jarod C. Finlay, Andreea Dimofte, Carmen Rodriguez, Keith Cengel, Eli Glatstein, Joseph Friedberg, Stephen M. Hahn

Surgery

University of Pennsylvania

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

13 Scopus citations

Abstract

Uniform light fluence distribution for patients undergoing photodynamic therapy (PDT) is critical to ensure predictable PDT outcome. However, common practice uses a point source to deliver light to the pleural cavity with the light uniformity monitored by 7 detectors placed within the pleural cavity. To improve the uniformity of light fluence rate distribution, we have used a real-time infrared (IR) tracking camera to track the movement of the light point source. The same tracking device is used to determine the surface contour of the treatment area. This study examines the light fluence (rate) delivered between the measurement and calculation in phantom studies. Isotropic detectors were used for in-vivo light dosimetry. Light fluence rate in the pleural cavity is calculated and compared with the in-vivo calculation. Phantom studies show that the surface contour can be determined with an accuracy of 2 mm, with maximum deviation of 5 mm. We can successfully match the calculated light fluence rates with the in-vivo measurements. Preliminary results indicate that the light fluence rate can have up to 50% deviation compared to the prescription in phantom experiments. The IR camera has been used successfully in pleural PDT patient treatment to track the motion of light source in realtime. We concluded that it is feasible to develop an IR camera based system to guide the motion of the light source to improve the uniformity of light distribution.

Original language	English
Title of host publication	Optical Methods for Tumor Treatment and Detection
Subtitle of host publication	Mechanisms and Techniques in Photodynamic Therapy XX
Volume	7886
DOIs	https://doi.org/10.1117/12.875635
State	Published - 2011
Event	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX - San Francisco, CA, United States Duration: Jan 22 2011 → Jan 23 2011

Publication series

Name	Proceedings of SPIE--the International Society for Optical Engineering
ISSN (Print)	0277-786X

Conference

Conference	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX
Country/Territory	United States
City	San Francisco, CA
Period	01/22/11 → 01/23/11

Keywords

intra-cavitary treatment planning
light dosimetry
light fluence
Photodynamic therapy

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10.1117/12.875635

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Zhu, T. C., Liang, X., Chang, C., Sandell, J., Finlay, J. C., Dimofte, A., Rodriguez, C., Cengel, K., Glatstein, E., Friedberg, J., & Hahn, S. M. (2011). An IR navigation system for real-time treatment guidance of pleural PDT. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX (Vol. 7886). Article 78860L (Proceedings of SPIE--the International Society for Optical Engineering). https://doi.org/10.1117/12.875635

@inproceedings{81592166464f42f58d500db37a48d8f7,

title = "An IR navigation system for real-time treatment guidance of pleural PDT",

abstract = "Uniform light fluence distribution for patients undergoing photodynamic therapy (PDT) is critical to ensure predictable PDT outcome. However, common practice uses a point source to deliver light to the pleural cavity with the light uniformity monitored by 7 detectors placed within the pleural cavity. To improve the uniformity of light fluence rate distribution, we have used a real-time infrared (IR) tracking camera to track the movement of the light point source. The same tracking device is used to determine the surface contour of the treatment area. This study examines the light fluence (rate) delivered between the measurement and calculation in phantom studies. Isotropic detectors were used for in-vivo light dosimetry. Light fluence rate in the pleural cavity is calculated and compared with the in-vivo calculation. Phantom studies show that the surface contour can be determined with an accuracy of 2 mm, with maximum deviation of 5 mm. We can successfully match the calculated light fluence rates with the in-vivo measurements. Preliminary results indicate that the light fluence rate can have up to 50% deviation compared to the prescription in phantom experiments. The IR camera has been used successfully in pleural PDT patient treatment to track the motion of light source in realtime. We concluded that it is feasible to develop an IR camera based system to guide the motion of the light source to improve the uniformity of light distribution.",

keywords = "intra-cavitary treatment planning, light dosimetry, light fluence, Photodynamic therapy",

author = "Zhu, {Timothy C.} and Xing Liang and Chang Chang and Julia Sandell and Finlay, {Jarod C.} and Andreea Dimofte and Carmen Rodriguez and Keith Cengel and Eli Glatstein and Joseph Friedberg and Hahn, {Stephen M.}",

year = "2011",

doi = "10.1117/12.875635",

language = "English",

isbn = "9780819484239",

volume = "7886",

series = "Proceedings of SPIE--the International Society for Optical Engineering",

booktitle = "Optical Methods for Tumor Treatment and Detection",

note = "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX ; Conference date: 22-01-2011 Through 23-01-2011",

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Zhu, TC, Liang, X, Chang, C, Sandell, J, Finlay, JC, Dimofte, A, Rodriguez, C, Cengel, K, Glatstein, E, Friedberg, J & Hahn, SM 2011, An IR navigation system for real-time treatment guidance of pleural PDT. in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX. vol. 7886, 78860L, Proceedings of SPIE--the International Society for Optical Engineering, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, San Francisco, CA, United States, 01/22/11. https://doi.org/10.1117/12.875635

An IR navigation system for real-time treatment guidance of pleural PDT. / Zhu, Timothy C.; Liang, Xing; Chang, Chang et al.
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX. Vol. 7886 2011. 78860L (Proceedings of SPIE--the International Society for Optical Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - An IR navigation system for real-time treatment guidance of pleural PDT

AU - Zhu, Timothy C.

AU - Liang, Xing

AU - Chang, Chang

AU - Sandell, Julia

AU - Finlay, Jarod C.

AU - Dimofte, Andreea

AU - Rodriguez, Carmen

AU - Cengel, Keith

AU - Glatstein, Eli

AU - Friedberg, Joseph

AU - Hahn, Stephen M.

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AB - Uniform light fluence distribution for patients undergoing photodynamic therapy (PDT) is critical to ensure predictable PDT outcome. However, common practice uses a point source to deliver light to the pleural cavity with the light uniformity monitored by 7 detectors placed within the pleural cavity. To improve the uniformity of light fluence rate distribution, we have used a real-time infrared (IR) tracking camera to track the movement of the light point source. The same tracking device is used to determine the surface contour of the treatment area. This study examines the light fluence (rate) delivered between the measurement and calculation in phantom studies. Isotropic detectors were used for in-vivo light dosimetry. Light fluence rate in the pleural cavity is calculated and compared with the in-vivo calculation. Phantom studies show that the surface contour can be determined with an accuracy of 2 mm, with maximum deviation of 5 mm. We can successfully match the calculated light fluence rates with the in-vivo measurements. Preliminary results indicate that the light fluence rate can have up to 50% deviation compared to the prescription in phantom experiments. The IR camera has been used successfully in pleural PDT patient treatment to track the motion of light source in realtime. We concluded that it is feasible to develop an IR camera based system to guide the motion of the light source to improve the uniformity of light distribution.

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ER -

An IR navigation system for real-time treatment guidance of pleural PDT

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Keywords

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