TY - JOUR
T1 - An Assessment of Ovarian Cancer Histotypes Across the African Diaspora
AU - George, Sophia H.L.
AU - Omotoso, Ayodele
AU - Pinto, Andre
AU - Mustapha, Aisha
AU - Sanchez-Covarrubias, Alex P.
AU - Umar, Usman Aliyu
AU - Umar, Ali Bala
AU - Oluwasola, Timothy Abiola
AU - Okolo, Clement Abu
AU - Anthony, Umeh Uchenna
AU - Ukekwe, Francis Ikechukwu
AU - Bakari, Maisaratu A.
AU - Dahiru, Aminu M.C.
AU - Abdullahi, Habiba Ibrahim
AU - Abimiku, Bawa Ahmed
AU - Abdurrahman, Aisha
AU - Usman, Asmau
AU - Ahmed, Saad Aliyu
AU - Usman, Hadiza Abdullahi
AU - Kabir, Abba
AU - Eleje, George Uchenna
AU - Chiemeka, Michael Emeka
AU - Nzeribe, Emily
AU - Nweke, Ikechukwu
AU - Kadas, Saidu Abubakar
AU - Suleiman, Dauda E.
AU - Ekanem, Etim
AU - Uche, Umemmuo Maureen
AU - Paul, Jibrin
AU - Agwu, Uzoma Maryrose
AU - Edegbe, Felix O.
AU - Anorlu, Rose I.
AU - Banjo, Adekunbiola
AU - Ajenifuja, Kayode Olusegun
AU - Fawole, Adegboyega Adisa
AU - Kazeem, Ibrahim O.O.
AU - Magaji, Francis
AU - Silas, Olugbenga
AU - Athanasius, Boma Precious
AU - Tamunomie, Nyengidiki Kennedy
AU - Bassey, Emem
AU - Abudu, Kunle
AU - Ango, Ibrahim G.
AU - Abdullahi, Kabiru
AU - Lawal, Ishak
AU - Kabir, Suleiman Aliyu
AU - Ekanem, Victor
AU - Ezeanochie, Michael
AU - Yahaya, Usman Rahman
AU - Castillo, Melissa Nicole
AU - Bahall, Vishal
AU - Chatrani, Vikash
AU - Brambury, Ian
AU - Bowe, Saida
AU - Halliday, Darron
AU - Bruney, George
AU - Butler, Raleigh
AU - Ragin, Camille
AU - Odedina, Folakemi
AU - Chamala, Srikar
AU - Schlumbrecht, Matthew
AU - Audu, Bala
N1 - Publisher Copyright:
Copyright © 2021 George, Omotoso, Pinto, Mustapha, Sanchez-Covarrubias, Umar, Umar, Oluwasola, Okolo, Anthony, Ukekwe, Bakari, Dahiru, Abdullahi, Abimiku, Abdurrahman, Usman, Ahmed, Usman, Kabir, Eleje, Chiemeka, Nzeribe, Nweke, Kadas, Suleiman, Ekanem, Uche, Paul, Agwu, Edegbe, Anorlu, Banjo, Ajenifuja, Fawole, Kazeem, Magaji, Silas, Athanasius, Tamunomie, Bassey, Abudu, Ango, Abdullahi, Lawal, Kabir, Ekanem, Ezeanochie, Yahaya, Castillo, Bahall, Chatrani, Brambury, Bowe, Halliday, Bruney, Butler, Ragin, Odedina, Chamala, Schlumbrecht and Audu.
PY - 2021/11/26
Y1 - 2021/11/26
N2 - Objective: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. Methods: Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05. Results: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). Conclusion: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.
AB - Objective: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. Methods: Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05. Results: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). Conclusion: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.
KW - Caribbean
KW - Nigeria
KW - black women
KW - epithelial ovarian cancer (EOC)
KW - germ cell
KW - ovarian cancer
KW - sex cord stromal
UR - http://www.scopus.com/inward/record.url?scp=85120938070&partnerID=8YFLogxK
U2 - 10.3389/fonc.2021.732443
DO - 10.3389/fonc.2021.732443
M3 - Article
C2 - 34900682
SN - 2234-943X
VL - 11
SP - 732443
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 732443
ER -