An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

Laura Senovilla; Ilio Vitale; Isabelle Martins; Oliver Kepp; Lorenzo Galluzzi; Laurence Zitvoge; Maria Castedo; Guido Kroemer

doi:10.4161/onco.22409

An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

Laura Senovilla, Ilio Vitale, Isabelle Martins, Oliver Kepp, Lorenzo Galluzzi, Laurence Zitvoge, Maria Castedo, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

Original language	English
Article number	e22409
Journal	Oncoimmunology
Volume	2
Issue number	1
DOIs	https://doi.org/10.4161/onco.22409
State	Published - Jan 2013
Externally published	Yes

Keywords

Breast carcinoma
Calreticulin
HMGB1
Hyperploidy
Immunogenic cell death
Mitotic catastrophe

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4161/onco.22409

Cite this

@article{fab95c12a9cf41ea94b051f5d07a7a67,

title = "An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells",

abstract = "One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.",

keywords = "Breast carcinoma, Calreticulin, HMGB1, Hyperploidy, Immunogenic cell death, Mitotic catastrophe",

author = "Laura Senovilla and Ilio Vitale and Isabelle Martins and Oliver Kepp and Lorenzo Galluzzi and Laurence Zitvoge and Maria Castedo and Guido Kroemer",

year = "2013",

month = jan,

doi = "10.4161/onco.22409",

language = "English",

volume = "2",

journal = "Oncoimmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "1",

}

TY - JOUR

T1 - An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

AU - Senovilla, Laura

AU - Vitale, Ilio

AU - Martins, Isabelle

AU - Kepp, Oliver

AU - Galluzzi, Lorenzo

AU - Zitvoge, Laurence

AU - Castedo, Maria

AU - Kroemer, Guido

PY - 2013/1

Y1 - 2013/1

N2 - One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

AB - One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

KW - Breast carcinoma

KW - Calreticulin

KW - HMGB1

KW - Hyperploidy

KW - Immunogenic cell death

KW - Mitotic catastrophe

UR - http://www.scopus.com/inward/record.url?scp=84880732251&partnerID=8YFLogxK

U2 - 10.4161/onco.22409

DO - 10.4161/onco.22409

M3 - Article

AN - SCOPUS:84880732251

SN - 2162-4011

VL - 2

JO - Oncoimmunology

JF - Oncoimmunology

IS - 1

M1 - e22409

ER -

An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this