An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen; Caitlin M. Roake; Adam Freund; Pedro J. Batista; Siqi Tian; Yi A. Yin; Chandresh R. Gajera; Shengda Lin; Byron Lee; Matthew F. Pech; Andrew S. Venteicher; Rhiju Das; Howard Y. Chang; Steven E. Artandi

doi:10.1016/j.cell.2018.04.039

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen
, Caitlin M. Roake
, Adam Freund
, Pedro J. Batista
, Siqi Tian
, Yi A. Yin
, Chandresh R. Gajera
, Shengda Lin
, Byron Lee
, Matthew F. Pech
, Andrew S. Venteicher
, Rhiju Das
, Howard Y. Chang
, Steven E. Artandi

Stanford University

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.

Original language	English
Pages (from-to)	218-230.e13
Journal	Cell
Volume	174
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2018.04.039
State	Published - Jun 28 2018

Keywords

Biocatalysis
Cell Line
HeLa Cells
Humans
Molecular Chaperones
Nuclear Proteins/deficiency
Nucleic Acid Conformation
Protein Binding
RNA Interference
RNA, Small Interfering/metabolism
RNA, Untranslated/chemistry
Telomerase/antagonists & inhibitors
Telomere/metabolism

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10.1016/j.cell.2018.04.039

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@article{7f5da6350342484fa466256cf2eecdea,

title = "An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1",

abstract = "The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.",

keywords = "Biocatalysis, Cell Line, HeLa Cells, Humans, Molecular Chaperones, Nuclear Proteins/deficiency, Nucleic Acid Conformation, Protein Binding, RNA Interference, RNA, Small Interfering/metabolism, RNA, Untranslated/chemistry, Telomerase/antagonists \& inhibitors, Telomere/metabolism",

author = "Lu Chen and Roake, \{Caitlin M.\} and Adam Freund and Batista, \{Pedro J.\} and Siqi Tian and Yin, \{Yi A.\} and Gajera, \{Chandresh R.\} and Shengda Lin and Byron Lee and Pech, \{Matthew F.\} and Venteicher, \{Andrew S.\} and Rhiju Das and Chang, \{Howard Y.\} and Artandi, \{Steven E.\}",

year = "2018",

month = jun,

day = "28",

doi = "10.1016/j.cell.2018.04.039",

language = "English",

volume = "174",

pages = "218--230.e13",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "1",

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T1 - An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

AU - Chen, Lu

AU - Roake, Caitlin M.

AU - Freund, Adam

AU - Batista, Pedro J.

AU - Tian, Siqi

AU - Yin, Yi A.

AU - Gajera, Chandresh R.

AU - Lin, Shengda

AU - Lee, Byron

AU - Pech, Matthew F.

AU - Venteicher, Andrew S.

AU - Das, Rhiju

AU - Chang, Howard Y.

AU - Artandi, Steven E.

PY - 2018/6/28

Y1 - 2018/6/28

N2 - The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.

AB - The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.

KW - Biocatalysis

KW - Cell Line

KW - HeLa Cells

KW - Humans

KW - Molecular Chaperones

KW - Nuclear Proteins/deficiency

KW - Nucleic Acid Conformation

KW - Protein Binding

KW - RNA Interference

KW - RNA, Small Interfering/metabolism

KW - RNA, Untranslated/chemistry

KW - Telomerase/antagonists & inhibitors

KW - Telomere/metabolism

UR - https://www.scopus.com/pages/publications/85047200227

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000437005800022&DestLinkType=FullRecord&DestApp=WOS

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DO - 10.1016/j.cell.2018.04.039

M3 - Article

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SN - 0092-8674

VL - 174

SP - 218-230.e13

JO - Cell

JF - Cell

IS - 1

ER -

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Abstract

Keywords

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