An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen; Caitlin M. Roake; Adam Freund; Pedro J. Batista; Siqi Tian; Yi A. Yin; Chandresh R. Gajera; Shengda Lin; Byron Lee; Matthew F. Pech; Andrew S. Venteicher; Rhiju Das; Howard Y. Chang; Steven E. Artandi

doi:10.1016/j.cell.2018.04.039

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen, Caitlin M. Roake, Adam Freund, Pedro J. Batista, Siqi Tian, Yi A. Yin, Chandresh R. Gajera, Shengda Lin, Byron Lee, Matthew F. Pech, Andrew S. Venteicher, Rhiju Das, Howard Y. Chang, Steven E. Artandi

Stanford University

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.

Original language	English
Pages (from-to)	218-230.e13
Journal	Cell
Volume	174
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2018.04.039
State	Published - Jun 28 2018

Keywords

Biocatalysis
Cell Line
HeLa Cells
Humans
Molecular Chaperones
Nuclear Proteins/deficiency
Nucleic Acid Conformation
Protein Binding
RNA Interference
RNA, Small Interfering/metabolism
RNA, Untranslated/chemistry
Telomerase/antagonists & inhibitors
Telomere/metabolism

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10.1016/j.cell.2018.04.039

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title = "An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1",

abstract = "The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.",

keywords = "Biocatalysis, Cell Line, HeLa Cells, Humans, Molecular Chaperones, Nuclear Proteins/deficiency, Nucleic Acid Conformation, Protein Binding, RNA Interference, RNA, Small Interfering/metabolism, RNA, Untranslated/chemistry, Telomerase/antagonists & inhibitors, Telomere/metabolism",

author = "Lu Chen and Roake, {Caitlin M.} and Adam Freund and Batista, {Pedro J.} and Siqi Tian and Yin, {Yi A.} and Gajera, {Chandresh R.} and Shengda Lin and Byron Lee and Pech, {Matthew F.} and Venteicher, {Andrew S.} and Rhiju Das and Chang, {Howard Y.} and Artandi, {Steven E.}",

year = "2018",

month = jun,

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doi = "10.1016/j.cell.2018.04.039",

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AU - Chen, Lu

AU - Roake, Caitlin M.

AU - Freund, Adam

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AU - Tian, Siqi

AU - Yin, Yi A.

AU - Gajera, Chandresh R.

AU - Lin, Shengda

AU - Lee, Byron

AU - Pech, Matthew F.

AU - Venteicher, Andrew S.

AU - Das, Rhiju

AU - Chang, Howard Y.

AU - Artandi, Steven E.

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AB - The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.

KW - Biocatalysis

KW - Cell Line

KW - HeLa Cells

KW - Humans

KW - Molecular Chaperones

KW - Nuclear Proteins/deficiency

KW - Nucleic Acid Conformation

KW - Protein Binding

KW - RNA Interference

KW - RNA, Small Interfering/metabolism

KW - RNA, Untranslated/chemistry

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KW - Telomere/metabolism

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VL - 174

SP - 218-230.e13

JO - Cell

JF - Cell

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An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Abstract

Keywords

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