TY - JOUR
T1 - Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology
AU - Chiorean, E. Gabriela
AU - Chiaro, Marco Del
AU - Tempero, Margaret A.
AU - Malafa, Mokenge P.
AU - Benson, Al B.
AU - Cardin, Dana B.
AU - Christensen, Jared A.
AU - Chung, Vincent
AU - Czito, Brian
AU - Dillhoff, Mary
AU - Donahue, Timothy R.
AU - Dotan, Efrat
AU - Fountzilas, Christos
AU - Glazer, Evan S.
AU - Hardacre, Jeffrey
AU - Hawkins, William G.
AU - Klute, Kelsey
AU - Ko, Andrew H.
AU - Kunstman, John W.
AU - LoConte, Noelle
AU - Lowy, Andrew M.
AU - Masood, Ashiq
AU - Moravek, Cassadie
AU - Nakakura, Eric K.
AU - Narang, Amol K.
AU - Nardo, Lorenzo
AU - Obando, Jorge
AU - Polanco, Patricio M.
AU - Reddy, Sushanth
AU - Reyngold, Marsha
AU - Scaife, Courtney
AU - Shen, Jeanne
AU - Truty, Mark J.
AU - Vollmer, Charles
AU - Wolff, Robert A.
AU - Wolpin, Brian M.
AU - McCullough, Beth
AU - Lubin, Senem
AU - Darlow, Susan D.
N1 - Publisher Copyright:
© 2023, National Comprehensive Cancer Network® (NCCN®). All rights reserved.
PY - 2023/7
Y1 - 2023/7
N2 - Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations encompassing the head of the pancreas, distal bile duct, duodenum, or ampulla of Vater. Ampullary cancers are rare gastrointestinal malignancies, and prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, and treatment modality received. Systemic therapy is used in all stages of ampullary cancer, including neoadjuvant therapy, adjuvant therapy, and first-line or subsequent-line therapy for locally advanced, metastatic, and recurrent disease. Radiation therapy may be used in localized ampullary cancer, sometimes in combination with chemotherapy, but there is no high-level evidence to support its utility. Select tumors may be treated surgically. This article describes NCCN recommendations regarding management of ampullary adenocarcinoma.
AB - Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations encompassing the head of the pancreas, distal bile duct, duodenum, or ampulla of Vater. Ampullary cancers are rare gastrointestinal malignancies, and prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, and treatment modality received. Systemic therapy is used in all stages of ampullary cancer, including neoadjuvant therapy, adjuvant therapy, and first-line or subsequent-line therapy for locally advanced, metastatic, and recurrent disease. Radiation therapy may be used in localized ampullary cancer, sometimes in combination with chemotherapy, but there is no high-level evidence to support its utility. Select tumors may be treated surgically. This article describes NCCN recommendations regarding management of ampullary adenocarcinoma.
KW - Adenocarcinoma/diagnosis
KW - Ampulla of Vater
KW - Common Bile Duct Neoplasms/diagnosis
KW - Duodenal Neoplasms/diagnosis
KW - Humans
KW - Pancreatic Neoplasms
UR - http://www.scopus.com/inward/record.url?scp=85164383189&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:001081197400009&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.6004/jnccn.2023.0034
DO - 10.6004/jnccn.2023.0034
M3 - Article
C2 - 37433437
SN - 1540-1405
VL - 21
SP - 753
EP - 782
JO - Journal of the National Comprehensive Cancer Network : JNCCN
JF - Journal of the National Comprehensive Cancer Network : JNCCN
IS - 7
ER -