ALK-rearranged renal cell carcinoma with gains of chromosomes 7 and 17q --- A case report

Muntha Chaudhari; Hafiz Anas Yahya; Jianming Pei; Gabriel J. DiNatale; Iryna Mahan; James Ryan Mark; Arthur S. Patchefsky; Matthew R. Zibelman; Shuanzeng Wei

doi:10.1016/j.eucr.2025.103219

ALK-rearranged renal cell carcinoma with gains of chromosomes 7 and 17q --- A case report

Muntha Chaudhari, Hafiz Anas Yahya, Jianming Pei, Gabriel J. DiNatale, Iryna Mahan, James Ryan Mark, Arthur S. Patchefsky, Matthew R. Zibelman, Shuanzeng Wei

Research output: Contribution to journal › Article › peer-review

Abstract

ALK-rearranged renal cell carcinoma (ALK-RCC) is a rare subtype of RCC. In this report we describe the first ALK-RCC with gains of chromosome 7 and 17q. A 39-year-old male presented with an 11.5 cm renal mass and underwent a left radical nephrectomy. The tumor cells demonstrate focal clear cytoplasm, papillary formation, and extensive sarcomatoid changes. Molecular tests showed ALK rearrangement and gains at chromosomes 7 and 17q, which are commonly seen in papillary renal cell carcinoma. Thus caution is advised when interpreting chromosomal alterations for renal cell carcinoma.

Original language	English
Article number	103219
Pages (from-to)	103219
Journal	Urology Case Reports
Volume	63
DOIs	https://doi.org/10.1016/j.eucr.2025.103219
State	Published - Nov 2025

Keywords

ALK rearranged
Case report
Gains of chromosomes 7 and 17q
Renal cell carcinoma

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10.1016/j.eucr.2025.103219

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title = "ALK-rearranged renal cell carcinoma with gains of chromosomes 7 and 17q --- A case report",

abstract = "ALK-rearranged renal cell carcinoma (ALK-RCC) is a rare subtype of RCC. In this report we describe the first ALK-RCC with gains of chromosome 7 and 17q. A 39-year-old male presented with an 11.5 cm renal mass and underwent a left radical nephrectomy. The tumor cells demonstrate focal clear cytoplasm, papillary formation, and extensive sarcomatoid changes. Molecular tests showed ALK rearrangement and gains at chromosomes 7 and 17q, which are commonly seen in papillary renal cell carcinoma. Thus caution is advised when interpreting chromosomal alterations for renal cell carcinoma.",

keywords = "ALK rearranged, Case report, Gains of chromosomes 7 and 17q, Renal cell carcinoma",

author = "Muntha Chaudhari and Yahya, \{Hafiz Anas\} and Jianming Pei and DiNatale, \{Gabriel J.\} and Iryna Mahan and Mark, \{James Ryan\} and Patchefsky, \{Arthur S.\} and Zibelman, \{Matthew R.\} and Shuanzeng Wei",

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year = "2025",

month = nov,

doi = "10.1016/j.eucr.2025.103219",

language = "English",

volume = "63",

pages = "103219",

journal = "Urology Case Reports",

issn = "2214-4420",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - ALK-rearranged renal cell carcinoma with gains of chromosomes 7 and 17q --- A case report

AU - Chaudhari, Muntha

AU - Yahya, Hafiz Anas

AU - Pei, Jianming

AU - DiNatale, Gabriel J.

AU - Mahan, Iryna

AU - Mark, James Ryan

AU - Patchefsky, Arthur S.

AU - Zibelman, Matthew R.

AU - Wei, Shuanzeng

PY - 2025/11

Y1 - 2025/11

N2 - ALK-rearranged renal cell carcinoma (ALK-RCC) is a rare subtype of RCC. In this report we describe the first ALK-RCC with gains of chromosome 7 and 17q. A 39-year-old male presented with an 11.5 cm renal mass and underwent a left radical nephrectomy. The tumor cells demonstrate focal clear cytoplasm, papillary formation, and extensive sarcomatoid changes. Molecular tests showed ALK rearrangement and gains at chromosomes 7 and 17q, which are commonly seen in papillary renal cell carcinoma. Thus caution is advised when interpreting chromosomal alterations for renal cell carcinoma.

AB - ALK-rearranged renal cell carcinoma (ALK-RCC) is a rare subtype of RCC. In this report we describe the first ALK-RCC with gains of chromosome 7 and 17q. A 39-year-old male presented with an 11.5 cm renal mass and underwent a left radical nephrectomy. The tumor cells demonstrate focal clear cytoplasm, papillary formation, and extensive sarcomatoid changes. Molecular tests showed ALK rearrangement and gains at chromosomes 7 and 17q, which are commonly seen in papillary renal cell carcinoma. Thus caution is advised when interpreting chromosomal alterations for renal cell carcinoma.

KW - ALK rearranged

KW - Case report

KW - Gains of chromosomes 7 and 17q

KW - Renal cell carcinoma

UR - https://www.scopus.com/pages/publications/105016553028

U2 - 10.1016/j.eucr.2025.103219

DO - 10.1016/j.eucr.2025.103219

M3 - Article

C2 - 41050524

AN - SCOPUS:105016553028

SN - 2214-4420

VL - 63

SP - 103219

JO - Urology Case Reports

JF - Urology Case Reports

M1 - 103219

ER -

ALK-rearranged renal cell carcinoma with gains of chromosomes 7 and 17q --- A case report

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