Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females

Sully Fernandez; John M. Viola; Ann Marie Torres; Martina Wallace; Sophie Trefely; Steven Zhao; Hayley C. Affronti; Jivani M. Gengatharan; David A. Guertin; Nathaniel W. Snyder; Christian M. Metallo; Kathryn E. Wellen

doi:10.1016/j.celrep.2019.04.112

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females

Sully Fernandez, John M. Viola, Ann Marie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, Kathryn E. Wellen

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Sugar is a major component of the modern diet. Fernandez et al. identify ATP-citrate lyase (ACLY) as a key facilitator of transcriptional and metabolic responses to dietary carbohydrates in adipocytes. Lack of adipocyte ACLY disrupts proper storage of lipids in adipose versus liver and promotes insulin resistance, particularly in females.

Original language	English
Pages (from-to)	2772-2784.e6
Journal	Cell Reports
Volume	27
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2019.04.112
State	Published - May 28 2019
Externally published	Yes

Keywords

ATP-citrate lyase
ChREBP
acetyl-CoA
adipocyte
adipose tissue
carbohydrate
fatty acid synthesis
glucose
liver
sexual dimorphism

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10.1016/j.celrep.2019.04.112

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Fernandez, S., Viola, J. M., Torres, A. M., Wallace, M., Trefely, S., Zhao, S., Affronti, H. C., Gengatharan, J. M., Guertin, D. A., Snyder, N. W., Metallo, C. M., & Wellen, K. E. (2019). Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females. Cell Reports, 27(9), 2772-2784.e6. https://doi.org/10.1016/j.celrep.2019.04.112

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title = "Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females",

abstract = "Sugar is a major component of the modern diet. Fernandez et al. identify ATP-citrate lyase (ACLY) as a key facilitator of transcriptional and metabolic responses to dietary carbohydrates in adipocytes. Lack of adipocyte ACLY disrupts proper storage of lipids in adipose versus liver and promotes insulin resistance, particularly in females.",

keywords = "ATP-citrate lyase, ChREBP, acetyl-CoA, adipocyte, adipose tissue, carbohydrate, fatty acid synthesis, glucose, liver, sexual dimorphism",

author = "Sully Fernandez and Viola, {John M.} and Torres, {Ann Marie} and Martina Wallace and Sophie Trefely and Steven Zhao and Affronti, {Hayley C.} and Gengatharan, {Jivani M.} and Guertin, {David A.} and Snyder, {Nathaniel W.} and Metallo, {Christian M.} and Wellen, {Kathryn E.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = may,

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doi = "10.1016/j.celrep.2019.04.112",

language = "English",

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AU - Fernandez, Sully

AU - Viola, John M.

AU - Torres, Ann Marie

AU - Wallace, Martina

AU - Trefely, Sophie

AU - Zhao, Steven

AU - Affronti, Hayley C.

AU - Gengatharan, Jivani M.

AU - Guertin, David A.

AU - Snyder, Nathaniel W.

AU - Metallo, Christian M.

AU - Wellen, Kathryn E.

PY - 2019/5/28

Y1 - 2019/5/28

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AB - Sugar is a major component of the modern diet. Fernandez et al. identify ATP-citrate lyase (ACLY) as a key facilitator of transcriptional and metabolic responses to dietary carbohydrates in adipocytes. Lack of adipocyte ACLY disrupts proper storage of lipids in adipose versus liver and promotes insulin resistance, particularly in females.

KW - ATP-citrate lyase

KW - ChREBP

KW - acetyl-CoA

KW - adipocyte

KW - adipose tissue

KW - carbohydrate

KW - fatty acid synthesis

KW - glucose

KW - liver

KW - sexual dimorphism

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AN - SCOPUS:85065803532

SN - 2211-1247

VL - 27

SP - 2772-2784.e6

JO - Cell Reports

JF - Cell Reports

IS - 9

ER -

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females

Abstract

Keywords

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