TY - JOUR
T1 - Adherence to the 2020 American Cancer Society Guideline for Cancer Prevention and risk of breast cancer for women at increased familial and genetic risk in the Breast Cancer Family Registry
T2 - an evaluation of the weight, physical activity, and alcohol consumption recommendations
AU - Geczik, Ashley M.
AU - Ferris, Jennifer S.
AU - Terry, Mary Beth
AU - Andrulis, Irene L.
AU - Buys, Saundra S.
AU - Daly, Mary
AU - Hopper, John L.
AU - John, Esther M.
AU - Kurian, Allison W.
AU - Southey, Melissa C.
AU - Liao, Yuyan
AU - Genkinger, Jeanine
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/8
Y1 - 2022/8
N2 - Purpose: The American Cancer Society (ACS) published an updated Guideline for Cancer Prevention (ACS Guideline) in 2020. Research suggests that adherence to the 2012 ACS Guideline might lower breast cancer risk, but there is limited evidence that this applies to women at increased familial and genetic risk of breast cancer. Methods: Using the Breast Cancer Family Registry (BCFR), a cohort enriched for increased familial and genetic risk of breast cancer, we examined adherence to three 2020 ACS Guideline recommendations (weight management (body mass index), physical activity, and alcohol consumption) with breast cancer risk in 9615 women. We used Cox proportional hazard regression modeling to calculate hazard ratios (HRs) and 95% confidence intervals (CI) overall and stratified by BRCA1 and BRCA2 pathogenic variant status, family history of breast cancer, menopausal status, and estrogen receptor-positive (ER +) breast cancer. Results: We observed 618 incident invasive or in situ breast cancers over a median 12.9 years. Compared with being adherent to none (n = 55 cancers), being adherent to any ACS recommendation (n = 563 cancers) was associated with a 27% lower breast cancer risk (HR = 0.73, 95% CI: 0.55–0.97). This was evident for women with a first-degree family history of breast cancer (HR = 0.68, 95% CI: 0.50–0.93), women without BRCA1 or BRCA2 pathogenic variants (HR = 0.71, 95% CI: 0.53–0.95), postmenopausal women (HR = 0.63, 95% CI: 0.44–0.89), and for risk of ER+ breast cancer (HR = 0.63, 95% CI: 0.40–0.98). Discussion: Adherence to the 2020 ACS Guideline recommendations for BMI, physical activity, and alcohol consumption could reduce breast cancer risk for postmenopausal women and women at increased familial risk.
AB - Purpose: The American Cancer Society (ACS) published an updated Guideline for Cancer Prevention (ACS Guideline) in 2020. Research suggests that adherence to the 2012 ACS Guideline might lower breast cancer risk, but there is limited evidence that this applies to women at increased familial and genetic risk of breast cancer. Methods: Using the Breast Cancer Family Registry (BCFR), a cohort enriched for increased familial and genetic risk of breast cancer, we examined adherence to three 2020 ACS Guideline recommendations (weight management (body mass index), physical activity, and alcohol consumption) with breast cancer risk in 9615 women. We used Cox proportional hazard regression modeling to calculate hazard ratios (HRs) and 95% confidence intervals (CI) overall and stratified by BRCA1 and BRCA2 pathogenic variant status, family history of breast cancer, menopausal status, and estrogen receptor-positive (ER +) breast cancer. Results: We observed 618 incident invasive or in situ breast cancers over a median 12.9 years. Compared with being adherent to none (n = 55 cancers), being adherent to any ACS recommendation (n = 563 cancers) was associated with a 27% lower breast cancer risk (HR = 0.73, 95% CI: 0.55–0.97). This was evident for women with a first-degree family history of breast cancer (HR = 0.68, 95% CI: 0.50–0.93), women without BRCA1 or BRCA2 pathogenic variants (HR = 0.71, 95% CI: 0.53–0.95), postmenopausal women (HR = 0.63, 95% CI: 0.44–0.89), and for risk of ER+ breast cancer (HR = 0.63, 95% CI: 0.40–0.98). Discussion: Adherence to the 2020 ACS Guideline recommendations for BMI, physical activity, and alcohol consumption could reduce breast cancer risk for postmenopausal women and women at increased familial risk.
KW - Breast Cancer
KW - Cancer Prevention
KW - Incidence
KW - Lifestyle behaviors
KW - Breast Neoplasms/etiology
KW - Humans
KW - Risk Factors
KW - American Cancer Society
KW - United States/epidemiology
KW - Exercise
KW - Female
KW - Registries
KW - Alcohol Drinking/adverse effects
UR - http://www.scopus.com/inward/record.url?scp=85133292948&partnerID=8YFLogxK
U2 - 10.1007/s10549-022-06656-7
DO - 10.1007/s10549-022-06656-7
M3 - Article
C2 - 35780210
SN - 0167-6806
VL - 194
SP - 673
EP - 682
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 3
ER -