Adherence to the 2020 American Cancer Society Guideline for Cancer Prevention and risk of breast cancer for women at increased familial and genetic risk in the Breast Cancer Family Registry: an evaluation of the weight, physical activity, and alcohol consumption recommendations

Ashley M. Geczik, Jennifer S. Ferris, Mary Beth Terry, Irene L. Andrulis, Saundra S. Buys, Mary Daly, John L. Hopper, Esther M. John, Allison W. Kurian, Melissa C. Southey, Yuyan Liao, Jeanine Genkinger

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The American Cancer Society (ACS) published an updated Guideline for Cancer Prevention (ACS Guideline) in 2020. Research suggests that adherence to the 2012 ACS Guideline might lower breast cancer risk, but there is limited evidence that this applies to women at increased familial and genetic risk of breast cancer. Methods: Using the Breast Cancer Family Registry (BCFR), a cohort enriched for increased familial and genetic risk of breast cancer, we examined adherence to three 2020 ACS Guideline recommendations (weight management (body mass index), physical activity, and alcohol consumption) with breast cancer risk in 9615 women. We used Cox proportional hazard regression modeling to calculate hazard ratios (HRs) and 95% confidence intervals (CI) overall and stratified by BRCA1 and BRCA2 pathogenic variant status, family history of breast cancer, menopausal status, and estrogen receptor-positive (ER +) breast cancer. Results: We observed 618 incident invasive or in situ breast cancers over a median 12.9 years. Compared with being adherent to none (n = 55 cancers), being adherent to any ACS recommendation (n = 563 cancers) was associated with a 27% lower breast cancer risk (HR = 0.73, 95% CI: 0.55–0.97). This was evident for women with a first-degree family history of breast cancer (HR = 0.68, 95% CI: 0.50–0.93), women without BRCA1 or BRCA2 pathogenic variants (HR = 0.71, 95% CI: 0.53–0.95), postmenopausal women (HR = 0.63, 95% CI: 0.44–0.89), and for risk of ER+ breast cancer (HR = 0.63, 95% CI: 0.40–0.98). Discussion: Adherence to the 2020 ACS Guideline recommendations for BMI, physical activity, and alcohol consumption could reduce breast cancer risk for postmenopausal women and women at increased familial risk.

Original languageEnglish
Pages (from-to)673-682
Number of pages10
JournalBreast Cancer Research and Treatment
Volume194
Issue number3
DOIs
StatePublished - Aug 2022

Keywords

  • Breast Cancer
  • Cancer Prevention
  • Incidence
  • Lifestyle behaviors
  • Breast Neoplasms/etiology
  • Humans
  • Risk Factors
  • American Cancer Society
  • United States/epidemiology
  • Exercise
  • Female
  • Registries
  • Alcohol Drinking/adverse effects

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