TY - JOUR
T1 - Adenomatous and carcinomatous changes within hyperplastic colonic epithelium
AU - Cooper, Harry S.
AU - Patchefsky, Arthur S.
AU - Marks, Gerald
PY - 1979/4
Y1 - 1979/4
N2 - Hyperplastic colonic polyps are benign, nonneoplastic proliferations; unlike tubular and villous adenomas, they do not predispose the patient to colonic cancer. Theoretically, these hyperplastic polyps, like normal colonic epithelium, should be able to undergo adenomatous transformation and possibly develop into cancer. In this report, we discuss an unusual case of a patient with numerous hyperplastic polyps, in which adenomatous changes occurred and cancer developed. We also discuss the significance of these changes as they relate to the polyp-cancer sequence.
AB - Hyperplastic colonic polyps are benign, nonneoplastic proliferations; unlike tubular and villous adenomas, they do not predispose the patient to colonic cancer. Theoretically, these hyperplastic polyps, like normal colonic epithelium, should be able to undergo adenomatous transformation and possibly develop into cancer. In this report, we discuss an unusual case of a patient with numerous hyperplastic polyps, in which adenomatous changes occurred and cancer developed. We also discuss the significance of these changes as they relate to the polyp-cancer sequence.
KW - Adenoma/pathology
KW - Aged
KW - Colon/pathology
KW - Colonic Neoplasms/pathology
KW - Epithelium/pathology
KW - Female
KW - Humans
KW - Hyperplasia
KW - Intestinal Polyps/pathology
KW - Precancerous Conditions/pathology
UR - http://www.scopus.com/inward/record.url?scp=0018748069&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1979GZ02800003&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1007/BF02586805
DO - 10.1007/BF02586805
M3 - Article
C2 - 446245
SN - 0012-3706
VL - 22
SP - 152
EP - 156
JO - Diseases of the Colon & Rectum
JF - Diseases of the Colon & Rectum
IS - 3
ER -