Acute myeloid leukemia and myelodysplastic syndrome following breast cancer: Increased frequency of other cancers and of cancers in multiple family members

Aruna Padmanabhan, Julie A. Baker, Gary Zirpoli, Sheila N.J. Sait, Laurie A. Ford, Kirsten B. Moysich, Maria R. Baer

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Adjuvant chemotherapy and radiation therapy for breast cancer are associated with therapy-related acute myeloid leukemia (AML)/myelodysplastic syndromes (MDS), but little is known about additional risk factors. Thirty-four patients with AML (n = 26)/MDS (n = 8) following breast cancer (cases) were compared with 2029 breast cancer patients without AML/MDS (controls). Cases were older at breast cancer diagnosis (mean 60.2 years versus 54.5 years; p = 0.01) and more commonly had additional cancers (29% versus 4.9%; p < 0.0001) and ≥4 first-degree relatives with any type of cancer (OR: 5.37, CI: 1.44-19.9). Thus risk factors for AML/MDS following breast cancer include older age, other cancers and multiple first-degree relatives with cancer.

Original languageEnglish
Pages (from-to)1820-1823
Number of pages4
JournalLeukemia Research
Volume32
Issue number12
DOIs
StatePublished - Dec 2008

Keywords

  • Acute myeloid eukemia
  • Breast cancer
  • Myelodysplastic syndrome
  • Risk assessment
  • Therapy-related

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