Abstract
Adjuvant chemotherapy and radiation therapy for breast cancer are associated with therapy-related acute myeloid leukemia (AML)/myelodysplastic syndromes (MDS), but little is known about additional risk factors. Thirty-four patients with AML (n = 26)/MDS (n = 8) following breast cancer (cases) were compared with 2029 breast cancer patients without AML/MDS (controls). Cases were older at breast cancer diagnosis (mean 60.2 years versus 54.5 years; p = 0.01) and more commonly had additional cancers (29% versus 4.9%; p < 0.0001) and ≥4 first-degree relatives with any type of cancer (OR: 5.37, CI: 1.44-19.9). Thus risk factors for AML/MDS following breast cancer include older age, other cancers and multiple first-degree relatives with cancer.
Original language | English |
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Pages (from-to) | 1820-1823 |
Number of pages | 4 |
Journal | Leukemia Research |
Volume | 32 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2008 |
Keywords
- Acute myeloid eukemia
- Breast cancer
- Myelodysplastic syndrome
- Risk assessment
- Therapy-related