Acute eosinophilic leukemia with a (10;11) chromosomal translocation

S. A. Fischkoff, J. R. Testa, C. A. Schiffer

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20 Scopus citations

Abstract

We report a patient with acute eosinophilic leukemia and a translocation (10;11)(p14;q21). Clinically, the disease was characterized by extreme hypereosinophilia with most eosinophils being immature, pronounced marrow infiltration with abnormal eosinophil precursors, skin and lymphoid infiltration with leukemic eosinophils, and only a brief remission from chemotherapy. This is the second report of a patient with this cytogenetic/clinicopathological association. In our patient, t(10;11)(p14;q21) was the sole karyotypic abnormality seen in the bone marrow, both at diagnosis and relapse. Thus, acute eosinophilic leukemia with t(10;11)(p14;q21) appears to be a rare, new clinical/cytogenetic association. Because both patients with this translocation responded only briefly to chemotherapy, this chromosomal abnormality may confer a poor prognosis.

Original languageEnglish
Pages (from-to)394-397
Number of pages4
JournalLeukemia
Volume2
Issue number6
StatePublished - 1988

Keywords

  • Adult
  • Chromosome Aberrations/genetics
  • Chromosome Disorders
  • Chromosomes, Human, Pair 10
  • Chromosomes, Human, Pair 11
  • Eosinophils
  • Humans
  • Karyotyping
  • Leukemia/drug therapy
  • Male
  • Translocation, Genetic

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