TY - JOUR
T1 - Acute eosinophilic leukemia with a (10;11) chromosomal translocation
AU - Fischkoff, S. A.
AU - Testa, J. R.
AU - Schiffer, C. A.
PY - 1988
Y1 - 1988
N2 - We report a patient with acute eosinophilic leukemia and a translocation (10;11)(p14;q21). Clinically, the disease was characterized by extreme hypereosinophilia with most eosinophils being immature, pronounced marrow infiltration with abnormal eosinophil precursors, skin and lymphoid infiltration with leukemic eosinophils, and only a brief remission from chemotherapy. This is the second report of a patient with this cytogenetic/clinicopathological association. In our patient, t(10;11)(p14;q21) was the sole karyotypic abnormality seen in the bone marrow, both at diagnosis and relapse. Thus, acute eosinophilic leukemia with t(10;11)(p14;q21) appears to be a rare, new clinical/cytogenetic association. Because both patients with this translocation responded only briefly to chemotherapy, this chromosomal abnormality may confer a poor prognosis.
AB - We report a patient with acute eosinophilic leukemia and a translocation (10;11)(p14;q21). Clinically, the disease was characterized by extreme hypereosinophilia with most eosinophils being immature, pronounced marrow infiltration with abnormal eosinophil precursors, skin and lymphoid infiltration with leukemic eosinophils, and only a brief remission from chemotherapy. This is the second report of a patient with this cytogenetic/clinicopathological association. In our patient, t(10;11)(p14;q21) was the sole karyotypic abnormality seen in the bone marrow, both at diagnosis and relapse. Thus, acute eosinophilic leukemia with t(10;11)(p14;q21) appears to be a rare, new clinical/cytogenetic association. Because both patients with this translocation responded only briefly to chemotherapy, this chromosomal abnormality may confer a poor prognosis.
KW - Adult
KW - Chromosome Aberrations/genetics
KW - Chromosome Disorders
KW - Chromosomes, Human, Pair 10
KW - Chromosomes, Human, Pair 11
KW - Eosinophils
KW - Humans
KW - Karyotyping
KW - Leukemia/drug therapy
KW - Male
KW - Translocation, Genetic
UR - http://www.scopus.com/inward/record.url?scp=0023893953&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1988P870000012&DestLinkType=FullRecord&DestApp=WOS
M3 - Article
C2 - 3374171
SN - 0887-6924
VL - 2
SP - 394
EP - 397
JO - Leukemia
JF - Leukemia
IS - 6
ER -