Active DNA demethylation in development, human disease, and cancer

Rossella Tricarico; Alfonso Bellacosa

doi:10.1007/978-4-431-55873-6_21

Active DNA demethylation in development, human disease, and cancer

Rossella Tricarico, Alfonso Bellacosa

Fox Chase Cancer Center

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Methylation of cytosine in DNA has long been known as an important mechanism of transcriptional regulation. While DNA methyltransferases have been well characterized, the existence of enzymes involved in cytosine demethylation has been questioned. However, in the past few years, through a convergence of biochemical and genetic studies, active DNA demethylation has been finally recognized as an important mechanism of epigenetic regulation. Here, we will review the biological processes that rely on active DNA demethylation, the relevant DNA demethylating activities, and the corresponding biochemical pathways. We will then describe the role of DNA demethylating factors in development and their alterations in human disease and cancer.

Original language	English
Title of host publication	DNA Replication, Recombination, and Repair
Subtitle of host publication	Molecular Mechanisms and Pathology
Publisher	Springer Japan
Pages	517-548
Number of pages	32
ISBN (Electronic)	9784431558736
ISBN (Print)	9784431558712
DOIs	https://doi.org/10.1007/978-4-431-55873-6_21
State	Published - Jan 1 2016

Keywords

5-carboxylcytosine
5-formylcytosine
5-hydroxymethylcytosine
Cancer
Development
Dna demethylation
Tdg
Tet

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-4-431-55873-6_21

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Active DNA demethylation in development, human disease, and cancer

Abstract

Keywords

UN SDGs

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