TY - JOUR
T1 - A review of neoplasms with MITF/MiT family translocations
AU - Wei, Shuanzeng
AU - Testa, Joseph R.
AU - Argani, Pedram
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/4
Y1 - 2022/4
N2 - Microphthalmia-associated transcription factor (MITF/MiT) family is a group of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors including TFE3 (TFEA), TFEB, TFEC and MITF. The first described neoplasms involving MITF family translocation were renal cell carcinomas with chromosome translocations involving ASPL-TFE3/t(X;17)(p11.23;q25) or MALAT1-TFEB/t(6;11) (p21.1;q12), and now it is known as MiT family translocation RCC in 2016 WHO classification. Translocations involving MITF family genes also are found in other tumor types, such as perivascular epithelioid cell neoplasm (PEComa), alveolar soft part sarcoma (ASPS), epithelioid hemangioendothelioma, ossifying fibromyxoid tumor (OFMT), and clear cell tumor with melanocytic differentiation and ACTIN-MITF translocation. In this review, we summarize the features of different types of neoplasms with MITF family translocations.
AB - Microphthalmia-associated transcription factor (MITF/MiT) family is a group of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors including TFE3 (TFEA), TFEB, TFEC and MITF. The first described neoplasms involving MITF family translocation were renal cell carcinomas with chromosome translocations involving ASPL-TFE3/t(X;17)(p11.23;q25) or MALAT1-TFEB/t(6;11) (p21.1;q12), and now it is known as MiT family translocation RCC in 2016 WHO classification. Translocations involving MITF family genes also are found in other tumor types, such as perivascular epithelioid cell neoplasm (PEComa), alveolar soft part sarcoma (ASPS), epithelioid hemangioendothelioma, ossifying fibromyxoid tumor (OFMT), and clear cell tumor with melanocytic differentiation and ACTIN-MITF translocation. In this review, we summarize the features of different types of neoplasms with MITF family translocations.
KW - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics
KW - Carcinoma, Renal Cell/pathology
KW - Humans
KW - Kidney Neoplasms/pathology
KW - Microphthalmia-Associated Transcription Factor/genetics
KW - Oncogene Proteins, Fusion/genetics
KW - Translocation, Genetic
UR - http://www.scopus.com/inward/record.url?scp=85131698161&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000809358100001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.14670/HH-18-426
DO - 10.14670/HH-18-426
M3 - Review article
C2 - 35107169
SN - 0213-3911
VL - 37
SP - 311
EP - 321
JO - Histology and Histopathology
JF - Histology and Histopathology
IS - 4
ER -