TY - JOUR
T1 - A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
AU - Bellacosa, Alfonso
AU - Testa, Joseph R.
AU - Staal, Stephen P.
AU - Tsichlis, Philip N.
PY - 1991
Y1 - 1991
N2 - The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.
AB - The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.
KW - Amino Acid Sequence
KW - Animals
KW - Mice
KW - Mink
KW - Mink Cell Focus-Inducing Viruses/genetics
KW - Molecular Sequence Data
KW - Oncogene Protein v-akt
KW - Oncogenes/genetics
KW - Protein Kinases/genetics
KW - Protein Serine-Threonine Kinases
KW - Protein-Tyrosine Kinases/genetics
KW - Retroviridae Proteins, Oncogenic/genetics
KW - Sequence Homology, Nucleic Acid
UR - http://www.scopus.com/inward/record.url?scp=0026095665&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1991GJ64200035&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1126/science.254.5029.274
DO - 10.1126/science.254.5029.274
M3 - Article
C2 - 1833819
SN - 0036-8075
VL - 254
SP - 274
EP - 277
JO - Science
JF - Science
IS - 5029
ER -