A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

Alfonso Bellacosa, Joseph R. Testa, Stephen P. Staal, Philip N. Tsichlis

Research output: Contribution to journalArticlepeer-review

829 Scopus citations

Abstract

The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.

Original languageEnglish
Pages (from-to)274-277
Number of pages4
JournalScience
Volume254
Issue number5029
DOIs
StatePublished - 1991

Keywords

  • Amino Acid Sequence
  • Animals
  • Mice
  • Mink
  • Mink Cell Focus-Inducing Viruses/genetics
  • Molecular Sequence Data
  • Oncogene Protein v-akt
  • Oncogenes/genetics
  • Protein Kinases/genetics
  • Protein Serine-Threonine Kinases
  • Protein-Tyrosine Kinases/genetics
  • Retroviridae Proteins, Oncogenic/genetics
  • Sequence Homology, Nucleic Acid

Fingerprint

Dive into the research topics of 'A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region'. Together they form a unique fingerprint.

Cite this