A real-time treatment guidance system for pleural PDT

Timothy C. Zhu, Xing Liang, Julia Sandell, Jarod C. Finlay, Andreea Dimofte, Carmen Rodriguez, Keith Cengel, Joseph Friedberg, Stephen M. Hahn, Eli Glatstein

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

7 Scopus citations

Abstract

Intrapleural photodynamic therapy (PDT) has been used as an adjuvant treatment with lung-sparing surgical treatment for mesothelioma. In the current intrapleural PDT protocol, a moving fiber-based point source is used to deliver the light and the light dose are monitored by 7 detectors placed in the pleural cavity. To improve the delivery of light dose uniformity, an infrared (IR) camera system is used to track the motion of the light sources. A treatment planning system uses feedback from the detectors as well as the IR camera to update light fluence distribution in real-time, which is used to guide the light source motion for uniform light dose distribution. We have reported previously the success of using IR camera to passively monitor the light fluence rate distribution. In this study, the real-time feedback has been implemented in the current system prototype, by transferring data from the IR camera to a computer at a rate of 20 Hz, and by calculation/displaying using Matlab. A dual-correction method is used in the feedback system, so that fluence calculation can match detector readings. Preliminary data from a phantom showed superior light uniformity using this method. Light fluence uniformity from patient treatments is also shown using the correction method dose model.

Original languageEnglish
Title of host publicationOptical Methods for Tumor Treatment and Detection
Subtitle of host publicationMechanisms and Techniques in Photodynamic Therapy XXI
DOIs
StatePublished - 2012
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI - San Francisco, CA, United States
Duration: Jan 21 2012Jan 22 2012

Publication series

NameProceedings of SPIE--the International Society for Optical Engineering
ISSN (Print)0277-786X

Conference

ConferenceOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI
Country/TerritoryUnited States
CitySan Francisco, CA
Period01/21/1201/22/12

Keywords

  • IR navigation
  • Photodynamic therapy
  • Pleural PDT

Fingerprint

Dive into the research topics of 'A real-time treatment guidance system for pleural PDT'. Together they form a unique fingerprint.

Cite this