A phosphoarginine containing peptide as an artificial SH2 ligand

Frank T. Hofmann; Claudia Lindemann; Helen Salia; Philipp Adamitzki; John Karanicolas; Florian P. Seebeck

doi:10.1039/c1cc13341a

A phosphoarginine containing peptide as an artificial SH2 ligand

Frank T. Hofmann, Claudia Lindemann, Helen Salia, Philipp Adamitzki, John Karanicolas, Florian P. Seebeck

Cancer Signaling and Microenvironment (CSM)

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22 Scopus citations

Abstract

We have developed a synthesis of phosphoarginine containing peptides using a bis(2,2,2-trichloroethyl) protected phosphoarginine derivative as building block. Binding studies and computer modelling demonstrate the ability of the SH2 domain from Src kinase to recognize a phosphoarginine-containing peptide in a phosphoryl group-dependent manner.

Original language	English
Pages (from-to)	10335-10337
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	37
DOIs	https://doi.org/10.1039/c1cc13341a
State	Published - Oct 7 2011

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AU - Salia, Helen

AU - Adamitzki, Philipp

AU - Karanicolas, John

AU - Seebeck, Florian P.

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N2 - We have developed a synthesis of phosphoarginine containing peptides using a bis(2,2,2-trichloroethyl) protected phosphoarginine derivative as building block. Binding studies and computer modelling demonstrate the ability of the SH2 domain from Src kinase to recognize a phosphoarginine-containing peptide in a phosphoryl group-dependent manner.

AB - We have developed a synthesis of phosphoarginine containing peptides using a bis(2,2,2-trichloroethyl) protected phosphoarginine derivative as building block. Binding studies and computer modelling demonstrate the ability of the SH2 domain from Src kinase to recognize a phosphoarginine-containing peptide in a phosphoryl group-dependent manner.

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A phosphoarginine containing peptide as an artificial SH2 ligand

Abstract

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