Abstract
We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.
Original language | English |
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Pages (from-to) | 572-574 |
Number of pages | 3 |
Journal | OncoImmunology |
Volume | 1 |
Issue number | 4 |
DOIs | |
State | Published - 2012 |
Keywords
- ITIM
- Inhibitory ligand
- NCR
- NK cells
- NKp44
- PCNA