A new rho(D) map to diffuse gastric cancer

Dorothy Benton; Jonathan Chernoff

doi:10.1158/2159-8290.CD-19-1327

A new rho(D) map to diffuse gastric cancer

Dorothy Benton
, Jonathan Chernoff

Cancer Signaling and Microenvironment (CSM)

Drexel University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Diffuse gastric cancer (DGC) is characterized by frequent missense mutations in the small GTPase RHOA, but the effects of this mutation on enzyme activity and signaling have been widely debated. In this issue, Zhang and colleagues show that the most common RHOA mutation in DGC, encoding RHOA Y42C, represents a gain of function; that a mouse model incorporating this mutation in association with loss of the E-cadherin gene CDH1 recapitulates many aspects of DGC; and that rationally designed therapeutics based on our understanding of RHOA signaling are promising agents for treating DGC. See related article by Zhang et al., p. 288.

Original language	English
Pages (from-to)	182-184
Number of pages	3
Journal	Cancer Discovery
Volume	10
Issue number	2
DOIs	https://doi.org/10.1158/2159-8290.CD-19-1327
State	Published - Jan 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Focal Adhesion Protein-Tyrosine Kinases
Gain of Function Mutation
Mice
Mutation
Mutation, Missense
Stomach Neoplasms

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10.1158/2159-8290.CD-19-1327

Cite this

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title = "A new rho(D) map to diffuse gastric cancer",

abstract = "Diffuse gastric cancer (DGC) is characterized by frequent missense mutations in the small GTPase RHOA, but the effects of this mutation on enzyme activity and signaling have been widely debated. In this issue, Zhang and colleagues show that the most common RHOA mutation in DGC, encoding RHOA Y42C, represents a gain of function; that a mouse model incorporating this mutation in association with loss of the E-cadherin gene CDH1 recapitulates many aspects of DGC; and that rationally designed therapeutics based on our understanding of RHOA signaling are promising agents for treating DGC. See related article by Zhang et al., p. 288. ",

keywords = "Animals, Focal Adhesion Protein-Tyrosine Kinases, Gain of Function Mutation, Mice, Mutation, Mutation, Missense, Stomach Neoplasms",

author = "Dorothy Benton and Jonathan Chernoff",

note = "{\textcopyright}2020 American Association for Cancer Research.",

year = "2020",

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doi = "10.1158/2159-8290.CD-19-1327",

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pages = "182--184",

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AU - Chernoff, Jonathan

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AB - Diffuse gastric cancer (DGC) is characterized by frequent missense mutations in the small GTPase RHOA, but the effects of this mutation on enzyme activity and signaling have been widely debated. In this issue, Zhang and colleagues show that the most common RHOA mutation in DGC, encoding RHOA Y42C, represents a gain of function; that a mouse model incorporating this mutation in association with loss of the E-cadherin gene CDH1 recapitulates many aspects of DGC; and that rationally designed therapeutics based on our understanding of RHOA signaling are promising agents for treating DGC. See related article by Zhang et al., p. 288.

KW - Animals

KW - Focal Adhesion Protein-Tyrosine Kinases

KW - Gain of Function Mutation

KW - Mice

KW - Mutation

KW - Mutation, Missense

KW - Stomach Neoplasms

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SN - 2159-8274

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JO - Cancer Discovery

JF - Cancer Discovery

IS - 2

ER -

A new rho(D) map to diffuse gastric cancer

Abstract

UN SDGs

Keywords

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