TY - JOUR
T1 - A new central scaffold for metastasis
T2 - Parsing HEF1/Cas-L/NEDD9
AU - O'Neill, Geraldine M.
AU - Seo, Sachiko
AU - Serebriiskii, Ilya G.
AU - Lessin, Stuart R.
AU - Golemis, Erica A.
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent prometastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 and highlight its importance in the response to extracellular cues that drive invasion and metastasis. As a metastatic "hub" for signaling in cancer, HEF1 may provide a useful target for drug discovery efforts.
AB - Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent prometastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 and highlight its importance in the response to extracellular cues that drive invasion and metastasis. As a metastatic "hub" for signaling in cancer, HEF1 may provide a useful target for drug discovery efforts.
UR - http://www.scopus.com/inward/record.url?scp=35148825060&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000249955500001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1158/0008-5472.CAN-07-1328
DO - 10.1158/0008-5472.CAN-07-1328
M3 - Article
C2 - 17908996
SN - 0008-5472
VL - 67
SP - 8975
EP - 8979
JO - Cancer Research
JF - Cancer Research
IS - 19
ER -
