A new and efficient synthetic route for the anxiolytic agent CL285032

Victor P. Ghidu; Marc A. Ilies; Tom Cullen; Robert Pollet; Magid Abou-Gharbia

doi:10.1016/j.bmcl.2010.11.017

A new and efficient synthetic route for the anxiolytic agent CL285032

Victor P. Ghidu, Marc A. Ilies, Tom Cullen, Robert Pollet, Magid Abou-Gharbia

Cancer Signaling and Microenvironment (CSM)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof.

Original language	English
Pages (from-to)	259-261
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2010.11.017
State	Published - Jan 1 2011

Keywords

Anxiolytic agent
Noise phobia
Triazolopyridazine synthesis

Access to Document

10.1016/j.bmcl.2010.11.017

Cite this

@article{c81df059f2e14b7794929e99395f3a57,

title = "A new and efficient synthetic route for the anxiolytic agent CL285032",

abstract = "CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof.",

keywords = "Anxiolytic agent, Noise phobia, Triazolopyridazine synthesis",

author = "Ghidu, {Victor P.} and Ilies, {Marc A.} and Tom Cullen and Robert Pollet and Magid Abou-Gharbia",

year = "2011",

month = jan,

day = "1",

doi = "10.1016/j.bmcl.2010.11.017",

language = "English",

volume = "21",

pages = "259--261",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "1",

}

TY - JOUR

T1 - A new and efficient synthetic route for the anxiolytic agent CL285032

AU - Ghidu, Victor P.

AU - Ilies, Marc A.

AU - Cullen, Tom

AU - Pollet, Robert

AU - Abou-Gharbia, Magid

PY - 2011/1/1

Y1 - 2011/1/1

N2 - CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof.

AB - CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof.

KW - Anxiolytic agent

KW - Noise phobia

KW - Triazolopyridazine synthesis

UR - http://www.scopus.com/inward/record.url?scp=78650523940&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2010.11.017

DO - 10.1016/j.bmcl.2010.11.017

M3 - Article

C2 - 21095124

AN - SCOPUS:78650523940

SN - 0960-894X

VL - 21

SP - 259

EP - 261

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

A new and efficient synthetic route for the anxiolytic agent CL285032

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this