A mitochondrial checkpoint to adaptive anticancer immunity

Oliver Kepp; Peng Liu; Guido Kroemer; Lorenzo Galluzzi

doi:10.1080/2162402X.2023.2271693

A mitochondrial checkpoint to adaptive anticancer immunity

Oliver Kepp
, Peng Liu
, Guido Kroemer
, Lorenzo Galluzzi

Centre de Recherche des Cordeliers
Université Paris-Sud
Université Paris-Saclay
Assistance publique – Hôpitaux de Paris
Cornell University

Research output: Contribution to journal › Comment/debate

3 Scopus citations

Abstract

BCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint.

Original language	English
Article number	2271693
Journal	Oncoimmunology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2023.2271693
State	Published - 2023
Externally published	Yes

Keywords

Antigen presentation
CGAS
immune checkpoint inhibitors
immunogenic cell death
mtDNA
type I interferon
Proto-Oncogene Proteins c-bcl-2

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10.1080/2162402X.2023.2271693

Cite this

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title = "A mitochondrial checkpoint to adaptive anticancer immunity",

abstract = "BCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint.",

keywords = "Antigen presentation, CGAS, immune checkpoint inhibitors, immunogenic cell death, mtDNA, type I interferon, Proto-Oncogene Proteins c-bcl-2",

author = "Oliver Kepp and Peng Liu and Guido Kroemer and Lorenzo Galluzzi",

note = "{\textcopyright} 2023 The Author(s). Published with license by Taylor \& Francis Group, LLC.",

year = "2023",

doi = "10.1080/2162402X.2023.2271693",

language = "English",

volume = "12",

journal = "Oncoimmunology",

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T1 - A mitochondrial checkpoint to adaptive anticancer immunity

AU - Kepp, Oliver

AU - Liu, Peng

AU - Kroemer, Guido

AU - Galluzzi, Lorenzo

PY - 2023

Y1 - 2023

N2 - BCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint.

AB - BCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint.

KW - Antigen presentation

KW - CGAS

KW - immune checkpoint inhibitors

KW - immunogenic cell death

KW - mtDNA

KW - type I interferon

KW - Proto-Oncogene Proteins c-bcl-2

UR - https://www.scopus.com/pages/publications/85174622569

U2 - 10.1080/2162402X.2023.2271693

DO - 10.1080/2162402X.2023.2271693

M3 - Comment/debate

C2 - 37860277

AN - SCOPUS:85174622569

SN - 2162-4011

VL - 12

JO - Oncoimmunology

JF - Oncoimmunology

IS - 1

M1 - 2271693

ER -

A mitochondrial checkpoint to adaptive anticancer immunity

Abstract

Keywords

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