A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai; Igor Astsaturov; Edna Cukierman; David G. DeNardo; Mikala Egeblad; Ronald M. Evans; Douglas Fearon; Florian R. Greten; Sunil R. Hingorani; Tony Hunter; Richard O. Hynes; Rakesh K. Jain; Tobias Janowitz; Claus Jorgensen; Alec C. Kimmelman; Mikhail G. Kolonin; Robert G. Maki; R. Scott Powers; Ellen Puré; Daniel C. Ramirez; Ruth Scherz-Shouval; Mara H. Sherman; Sheila Stewart; Thea D. Tlsty; David A. Tuveson; Fiona M. Watt; Valerie Weaver; Ashani T. Weeraratna; Zena Werb

doi:10.1038/s41568-019-0238-1

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai, Igor Astsaturov, Edna Cukierman, David G. DeNardo, Mikala Egeblad, Ronald M. Evans, Douglas Fearon, Florian R. Greten, Sunil R. Hingorani, Tony Hunter, Richard O. Hynes, Rakesh K. Jain, Tobias Janowitz, Claus Jorgensen, Alec C. Kimmelman, Mikhail G. Kolonin, Robert G. Maki, R. Scott Powers, Ellen Puré, Daniel C. RamirezRuth Scherz-Shouval, Mara H. Sherman, Sheila Stewart, Thea D. Tlsty, David A. Tuveson, Fiona M. Watt, Valerie Weaver, Ashani T. Weeraratna, Zena Werb

Research output: Contribution to journal › Review article › peer-review

2262 Scopus citations

Abstract

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.

Original language	English
Pages (from-to)	174-186
Number of pages	13
Journal	Nature Reviews Cancer
Volume	20
Issue number	3
DOIs	https://doi.org/10.1038/s41568-019-0238-1
State	Published - Mar 1 2020

Keywords

Animals
Biomarkers
Cancer-Associated Fibroblasts/drug effects
Cell Plasticity
Clinical Trials as Topic
Disease Susceptibility
Humans
Molecular Targeted Therapy
Neoplasms/drug therapy
Signal Transduction
Stromal Cells/drug effects
Treatment Outcome
Tumor Microenvironment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41568-019-0238-1

Cite this

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., Hynes, R. O., Jain, R. K., Janowitz, T., Jorgensen, C., Kimmelman, A. C., Kolonin, M. G., Maki, R. G., Powers, R. S., Puré, E., ... Werb, Z. (2020). A framework for advancing our understanding of cancer-associated fibroblasts. Nature Reviews Cancer, 20(3), 174-186. https://doi.org/10.1038/s41568-019-0238-1

@article{77fc2217f047405fac6146cb57793b1b,

title = "A framework for advancing our understanding of cancer-associated fibroblasts",

abstract = "Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.",

keywords = "Animals, Biomarkers, Cancer-Associated Fibroblasts/drug effects, Cell Plasticity, Clinical Trials as Topic, Disease Susceptibility, Humans, Molecular Targeted Therapy, Neoplasms/drug therapy, Signal Transduction, Stromal Cells/drug effects, Treatment Outcome, Tumor Microenvironment",

author = "Erik Sahai and Igor Astsaturov and Edna Cukierman and DeNardo, {David G.} and Mikala Egeblad and Evans, {Ronald M.} and Douglas Fearon and Greten, {Florian R.} and Hingorani, {Sunil R.} and Tony Hunter and Hynes, {Richard O.} and Jain, {Rakesh K.} and Tobias Janowitz and Claus Jorgensen and Kimmelman, {Alec C.} and Kolonin, {Mikhail G.} and Maki, {Robert G.} and Powers, {R. Scott} and Ellen Pur{\'e} and Ramirez, {Daniel C.} and Ruth Scherz-Shouval and Sherman, {Mara H.} and Sheila Stewart and Tlsty, {Thea D.} and Tuveson, {David A.} and Watt, {Fiona M.} and Valerie Weaver and Weeraratna, {Ashani T.} and Zena Werb",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = mar,

day = "1",

doi = "10.1038/s41568-019-0238-1",

language = "English",

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Sahai, E, Astsaturov, I , Cukierman, E, DeNardo, DG, Egeblad, M, Evans, RM, Fearon, D, Greten, FR, Hingorani, SR, Hunter, T, Hynes, RO, Jain, RK, Janowitz, T, Jorgensen, C, Kimmelman, AC, Kolonin, MG, Maki, RG, Powers, RS, Puré, E, Ramirez, DC, Scherz-Shouval, R, Sherman, MH, Stewart, S, Tlsty, TD, Tuveson, DA, Watt, FM, Weaver, V, Weeraratna, AT & Werb, Z 2020, 'A framework for advancing our understanding of cancer-associated fibroblasts', Nature Reviews Cancer, vol. 20, no. 3, pp. 174-186. https://doi.org/10.1038/s41568-019-0238-1

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AU - Sahai, Erik

AU - Astsaturov, Igor

AU - Cukierman, Edna

AU - DeNardo, David G.

AU - Egeblad, Mikala

AU - Evans, Ronald M.

AU - Fearon, Douglas

AU - Greten, Florian R.

AU - Hingorani, Sunil R.

AU - Hunter, Tony

AU - Hynes, Richard O.

AU - Jain, Rakesh K.

AU - Janowitz, Tobias

AU - Jorgensen, Claus

AU - Kimmelman, Alec C.

AU - Kolonin, Mikhail G.

AU - Maki, Robert G.

AU - Powers, R. Scott

AU - Puré, Ellen

AU - Ramirez, Daniel C.

AU - Scherz-Shouval, Ruth

AU - Sherman, Mara H.

AU - Stewart, Sheila

AU - Tlsty, Thea D.

AU - Tuveson, David A.

AU - Watt, Fiona M.

AU - Weaver, Valerie

AU - Weeraratna, Ashani T.

AU - Werb, Zena

PY - 2020/3/1

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N2 - Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.

AB - Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.

KW - Animals

KW - Biomarkers

KW - Cancer-Associated Fibroblasts/drug effects

KW - Cell Plasticity

KW - Clinical Trials as Topic

KW - Disease Susceptibility

KW - Humans

KW - Molecular Targeted Therapy

KW - Neoplasms/drug therapy

KW - Signal Transduction

KW - Stromal Cells/drug effects

KW - Treatment Outcome

KW - Tumor Microenvironment

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U2 - 10.1038/s41568-019-0238-1

DO - 10.1038/s41568-019-0238-1

M3 - Review article

C2 - 31980749

SN - 1474-175X

VL - 20

SP - 174

EP - 186

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 3

ER -

A framework for advancing our understanding of cancer-associated fibroblasts

Abstract

Keywords

UN SDGs

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A framework for advancing our understanding of cancer-associated fibroblasts

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

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Biological Imaging Facility

Biosample Repository Facility

Histopathology Facility

Cite this