A Comparative Trial of Improving Care for Underserved Asian Americans Infected with Hepatitis B Virus

Grace X. Ma, Lin Zhu, Yin Tan, Shumenghui Zhai, Xiaoli Ma, Olorunseun O. Ogunwobi, Wei Jenny Yang, Tsunyou Ting, Sara Kim, Min Qi Wang

Research output: Contribution to journalArticlepeer-review


Background: Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC). Asian Americans have the highest incidence and mortality rates of HCC among all US racial/ethnic groups. Inadequate monitoring and treatment of chronic hepatitis B contribute to poor health outcomes and increased healthcare costs among Asian Americans. Aims: The goal of this study is to assess the effect of a patient-led strategy on chronic hepatitis B monitoring and treatment adherence specifically among Asian Americans with culturally tailored Patient Navigator-led Intervention. Methods: From 2015 to 2018, 532 eligible participants living with chronic hepatitis B in the greater Philadelphia and New York city metropolitan areas were randomly assigned to either the intervention group or the control group. Generalized linear mixed-effects models were used to estimate the odds ratio (OR) for rates of doctor visits for chronic hepatitis B and rates of alanine aminotransferase testing for evidence of liver damage. Results: Intervention group had higher rates of doctor visits than the control group at both 6-month (77.22% vs. 45.75%) and 12-month assessments (90.73% vs. 60.61%). Significantly more intervention group participants received ALT testing than control group participants at 6-month (52.90% vs. 25.10%) and 12-month (75.40% vs. 46.75%) follow-up. Conclusions: Culturally and linguistically appropriate intervention has strong effects on adherence to follow-up care among Asian American hepatitis B patients experiencing challenges to medication adherence and follow up care. These findings further identify opportunities for practical implementation of evidence-based intervention that could lead to reductions in disparities in chronic liver disease and liver cancer among high-risk, underserved populations.

Original languageEnglish
Pages (from-to)2333-2343
Number of pages11
JournalDigestive Diseases and Sciences
Issue number6
StatePublished - Jun 2023


  • Asian
  • Carcinoma, Hepatocellular
  • Hepatitis B virus
  • Hepatitis B, Chronic/drug therapy
  • Hepatitis B/complications
  • Humans
  • Liver Neoplasms/etiology
  • Quality Improvement
  • Treatment adherence
  • Chronic hepatitis B
  • Asian Americans
  • Monitoring


Dive into the research topics of 'A Comparative Trial of Improving Care for Underserved Asian Americans Infected with Hepatitis B Virus'. Together they form a unique fingerprint.

Cite this