A case of acute lymphoblastic leukemia with severe hypodiploidy

Shinichi Misawa, Nobuo Oguma, Joseph R. Testa

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A case of acute lymphoblastic leukemia with a severe hypodiploid chromosome constitution is reported. The modal chromosome number was 36, and the karyotype of these cells was 36,X, -X, -2, -3, -5, -7, -9, -12, -13, -15, -16, -17, -20, +21, +mar,del(1) (p13.1p22.3),inv(3)(q13.3q29). In addition to a haploid set, extra copies of chromosomes #6, #10, #14, #18, and #21 were found, as in most cases with severe hypodiploid karyotypes. A second, near-triploid cell line was also observed. An examination of chromosomal heteromorphisms suggested that the severe hypodiploid clone originated either from a near-triploid cell or from a common precursor cell.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume16
Issue number2
DOIs
StatePublished - Mar 15 1985

Keywords

  • Chromosome Aberrations
  • Chromosome Banding
  • Female
  • Humans
  • Karyotyping
  • Leukemia, Lymphoid/genetics
  • Middle Aged
  • Ploidies

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