TY - JOUR
T1 - A case of acute lymphoblastic leukemia with severe hypodiploidy
AU - Misawa, Shinichi
AU - Oguma, Nobuo
AU - Testa, Joseph R.
PY - 1985/3/15
Y1 - 1985/3/15
N2 - A case of acute lymphoblastic leukemia with a severe hypodiploid chromosome constitution is reported. The modal chromosome number was 36, and the karyotype of these cells was 36,X, -X, -2, -3, -5, -7, -9, -12, -13, -15, -16, -17, -20, +21, +mar,del(1) (p13.1p22.3),inv(3)(q13.3q29). In addition to a haploid set, extra copies of chromosomes #6, #10, #14, #18, and #21 were found, as in most cases with severe hypodiploid karyotypes. A second, near-triploid cell line was also observed. An examination of chromosomal heteromorphisms suggested that the severe hypodiploid clone originated either from a near-triploid cell or from a common precursor cell.
AB - A case of acute lymphoblastic leukemia with a severe hypodiploid chromosome constitution is reported. The modal chromosome number was 36, and the karyotype of these cells was 36,X, -X, -2, -3, -5, -7, -9, -12, -13, -15, -16, -17, -20, +21, +mar,del(1) (p13.1p22.3),inv(3)(q13.3q29). In addition to a haploid set, extra copies of chromosomes #6, #10, #14, #18, and #21 were found, as in most cases with severe hypodiploid karyotypes. A second, near-triploid cell line was also observed. An examination of chromosomal heteromorphisms suggested that the severe hypodiploid clone originated either from a near-triploid cell or from a common precursor cell.
KW - Chromosome Aberrations
KW - Chromosome Banding
KW - Female
KW - Humans
KW - Karyotyping
KW - Leukemia, Lymphoid/genetics
KW - Middle Aged
KW - Ploidies
UR - http://www.scopus.com/inward/record.url?scp=0021916803&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1985ADJ9100007&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/0165-4608(85)90007-X
DO - 10.1016/0165-4608(85)90007-X
M3 - Article
C2 - 3855691
SN - 0165-4608
VL - 16
SP - 137
EP - 143
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -