A β-boronopeptide bundle of known structure as a vehicle for polyol recognition

Michael S. Melicher, John Chu, Allison S. Walker, Scott J. Miller, Richard H.G. Baxter, Alanna Schepartz

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Despite significant progress in the design of receptors and sensors for simple polyols and monosaccharides, few synthetic receptors discriminate among multiple saccharide units simultaneously, especially under physiological conditions. Described here is the three-dimensional structure of a supramolecular complex - a β-peptide bundle - designed for the potential to interact simultaneously with as many as eight discrete monosaccharide units. The preliminary evaluation of this construct as a vehicle for polyol binding is also presented.

Original languageEnglish
Pages (from-to)5048-5051
Number of pages4
JournalOrganic Letters
Volume15
Issue number19
DOIs
StatePublished - Oct 4 2013

Keywords

  • Molecular Structure
  • Monosaccharides/chemistry
  • Peptides/chemistry
  • Polymers/chemistry

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