Research output per year
Research output per year
Personal profile
Professional Information
Lab Overview
My laboratory is mainly focused on the immune regulatory mechanisms in human lymphoid malignancies, with a particular interest in signaling transduction pathways and ubiquitin-dependent non-proteolytic/proteolytic machineries in lymphoma pathogenesis. Gaining insight into the pathological roles of these regulatory pathways can lead to improved understanding of the molecular circuitry that drives tumor survival and shapes the tumor microenvironment, as well as providing novel intervention strategies for targeted therapy and immunotherapy.
Research interests
Immune Signaling and Regulatory Pathways in Lymphoid Malignancies
- Identifying previously unrecognized molecular effectors that drive tumor immune escape, in order to provide opportunities to improve immunotherapeutic intervention strategies in lymphoma.
- Identifying novel immune signaling molecular — “addictions” — of cancer cells that could be exploited therapeutically, and defining the molecular mechanism by which these immune pathways contribute to tumor initiation and maintenance.
- Investigating the mechanism and the effectiveness of promising anti-cancer drugs, to develop therapeutic strategies to overcome drug resistance in lymphoma that are both effective and safe
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Collaborations and top research areas from the last five years
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Correction: Genome-wide CRISPR screen identifies MAD2L1BP and ANAPC15 as targets for brentuximab vedotin sensitivity in CD30+ peripheral T-cell lymphoma
Suto, K., Takei, N., Yokoyama, K., Chiba, M., Ishio, T., Maeda, M., Goto, H., Endo, T., Teshima, T., Yang, Y. & Nakagawa, M., Dec 2025, In: Leukemia. 39, 12, p. 3061 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
EBV-positive Hodgkin lymphoma with immunosuppressive microenvironment during IL-23 inhibitor therapy for psoriasis
Shah, B., Franco-Barraza, J., Cai, K. Q., Dmitrieva, M., Messmer, M., Yang, Y., Wasik, M., Cukierman, E. & Nejati, R., Apr 11 2025, In: medRxiv.Research output: Contribution to journal › Article › peer-review
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Genome-wide CRISPR screen identifies MAD2L1BP and ANAPC15 as targets for brentuximab vedotin sensitivity in CD30+ peripheral T-cell lymphoma
Suto, K., Takei, N., Yokoyama, K., Chiba, M., Ishio, T., Maeda, M., Goto, H., Endo, T., Teshima, T., Yang, Y. & Nakagawa, M., Jan 2025, In: Leukemia. 39, 1, p. 243-247 5 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The IL-1R and NFKBIZ pathway mediates immunoregulatory responses and immunotherapy efficacy in anaplastic large cell lymphoma
Wei, W., Song, Z., Wang, Y., Li, S., Tan, L., Lee, J., Cai, K. Q., Nejati, R., Kadin, M. E., Campbell, K. S., Nakagawa, M. & Yang, Y., Nov 12 2025, (E-pub ahead of print) In: Leukemia. 40, 1, p. 152-165 14 p.Research output: Contribution to journal › Article › peer-review
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Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer
Murayama, T., Nakayama, J., Jiang, X., Miyata, K., Morris, A. D., Cai, K. Q., Prasad, R. M., Ma, X., Efimov, A., Belani, N., Gerstein, E. R., Tan, Y., Zhou, Y., Kim, W., Maruyama, R., Campbell, K. S., Chen, L., Yang, Y., Balachandran, S. & Canadas, I., 2024, In: Cancer Discovery. 14, 3, p. 468-491 24 p.Research output: Contribution to journal › Article › peer-review
Open Access61 Scopus citations
Press/Media
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Researchers from Fox Chase Cancer Center Discuss Findings in Anaplastic Large Cell Lymphoma (The IL-1R and NFKBIZ pathway mediates immunoregulatory responses and immunotherapy efficacy in anaplastic large cell lymphoma)
Cai, K. Q., Nejati, R. M., Yang, Y. & Campbell, K. S.
11/25/25
1 item of Media coverage
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Late-stage diagnosis and its impact on survival in Pakistani women with cervical cancer: Findings from an institutional cancer registry.
10/31/25
1 item of Media coverage
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MAM Domain Containing 2 (MAMDC2) Affects Invasion and Metastasis of Human Gastric Cancer
05/26/25
1 item of Media coverage
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Outperforming Traditional Staging: A Novel Nomogram for HR-Positive Breast Cancer
02/24/25
1 item of Media coverage
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Efficacy and Safety of Neoadjuvant Immunotherapy Combined with Sandwich Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma: A Retrospective Study
11/29/24
1 item of Media coverage
Press/Media