Personal profile
Professional Information
Lab Overview
Work closely with biologists as well as clinical research teams to identify critical questions that can be addressed via computational approaches. Define and implement computational analysis plans to advance our research in cancer biology and also the development of potential novel translational therapeutic agents.
Analysis of various –omic-scale data including RNA-Seq, Exome and Whole Genome Sequencing and high throughput screening in order to nominate novel drug targets, enable patient enrichment strategies, understand mechanisms of resistance to therapies.
Integration and mining of large scale external data sets (TCGA, 1KG, EXAC, Cosmic) to further our understanding of the relationship between tumor genetics, the tumor microenvironment, and response to therapies.
Research interests
- Implement computational and statistical methods to analyze and interpret complex, high-throughput biological and genomic data
- Apply the most advanced pathway and network analysis to elucidate the perturbation of cellular mechanisms through observed genomic changes in different biological and disease conditions
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Collaborations and top research areas from the last five years
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B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice
Hayakawa, K., Zhou, Y. & Shinton, S. A., Mar 3 2024, In: Immunity and Ageing. 21, 1, p. 22 22.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer
Vendramini-Costa, D. B., Francescone, R., Franco-Barraza, J., Luong, T., Graves, M., de Aquino, A. M., Steele, N., Gardiner, J. C., Dos Santos, S. A. A., Ogier, C., Malloy, E., Borghaei, L., Martinez, E., Zhigarev, D. I., Tan, Y., Lee, H., Zhou, Y., Cai, K. Q., Klein-Szanto, A. J. & Wang, H. & 4 others, , Apr 18 2024, (bioRxiv).Research output: Working paper › Preprint
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SAR-096: Phase II clinical trial of ribociclib in combination with everolimus in advanced dedifferentiated liposarcoma (DDL), and leiomyosarcoma (LMS): Phase II Clinical Trial of Ribociclib in Combination with Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)
Movva, S., Matloob, S., Handorf, E. A., Choy, E., Merriam, P., Flieder, D. B., Cai, K. Q., Zhou, Y., Tetzlaff, E. D., Pagan, C., Barker, E., Veggeberg, R., Zumpano, D., Rink, L., von Mehren, M. & George, S., Jan 15 2024, In: Clinical Cancer Research. 30, 2, p. 315-322 8 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer
Murayama, T., Nakayama, J., Jiang, X., Miyata, K., Morris, A. D., Cai, K. Q., Prasad, R. M., Ma, X., Efimov, A., Belani, N., Gerstein, E. R., Tan, Y., Zhou, Y., Kim, W., Maruyama, R., Campbell, K. S., Chen, L., Yang, Y., Balachandran, S. & Canadas, I., 2024, In: Cancer Discovery. 14, 3, p. 468-491 24 p.Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations -
Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1–mediated immune suppression during GVHD
Wang, Y., He, S., Calendo, G., Bui, T., Tian, Y., Lee, C. Y., Zhou, Y., Zhao, X., Abraham, C., Mo, W., Chen, M., Sanders-Braggs, R., Madzo, J., Issa, J. P., Hexner, E. O., Wiest, D. L., Reshef, R., Xue, H. H. & Zhang, Y., Jan 11 2024, In: Blood. 143, 2, p. 166-177 12 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations
Press/Media
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U.S. Patents Awarded to Inventors in Pennsylvania (Jan. 29)
01/29/25
1 item of Media coverage
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U.S. Patents Awarded to Inventors in Pennsylvania (Sept. 18)
09/18/24
1 item of Media coverage
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U.S. Patents Awarded to Inventors in Pennsylvania (May 29)
05/29/24
1 item of Media coverage
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U.S. Patents Awarded to Inventors in Pennsylvania (May 22)
05/22/24
1 item of Media coverage
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