Research output per year
Research output per year
Personal profile
Personal profile
Lab Overview
We study the mechanisms of prostate cancer development and therapy resistance. We leverage cutting-edge animal and organoid modeling technologies, genetic engineering, functional genetics and genomic approaches to dissect the molecular underpinnings of prostate cancer initiation, progression, and therapy resistance, with an interest in both cancer cell intrinsic pathways and cell-cell interactions in the tumor microenvironment. Our goal is to make mechanistic discoveries that drive the development of innovative cancer therapies to improve patient outcomes.
Research interests
Biology and Vulnerability of Prostate Cancer
- Molecular mechanisms of lineage fate decisions in prostate cancer initiation and therapy resistance
- Targeting the transcriptional and epigenetic vulnerabilities of oncogenic drivers
- Spatial-temporal dynamics and vulnerabilities within the tumor microenvironment during cancer progression
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Collaborations and top research areas from the last five years
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ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L
Feng, W., Ladewig, E., Lange, M., Salsabeel, N., Zhao, H., Lee, Y. S., Gopalan, A., Luo, H., Kang, W., Fan, N., Rosiek, E., de Stanchina, E., Chen, Y., Carver, B. S., Leslie, C. S. & Sawyers, C. L., Sep 2025, In: Nature Genetics. 57, 9, p. 2177-2191 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
Lim, P. X., Zaman, M., Feng, W. & Jasin, M., Feb 1 2024, In: Molecular Cell. 84, 3, p. 447-462.e10 27 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity
Feng, W., Ladewig, E., Salsabeel, N., Zhao, H., Lee, Y. S., Gopalan, A., Lange, M., Luo, H., Kang, W., Fan, N., Rosiek, E., de Stanchina, E., Chen, Y., Carver, B. S., Leslie, C. S. & Sawyers, C. L., Mar 6 2024, (bioRxiv : the preprint server for biology).Research output: Working paper › Preprint
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Lysosome-dependent FOXA1 ubiquitination contributes to luminal lineage of advanced prostate cancer
Celada, S. I., Li, G., Celada, L. J., Lu, W., Kanagasabai, T., Feng, W., Cao, Z., Salsabeel, N., Mao, N., Brown, L. K., Mark, Z. A., Izban, M. G., Ballard, B. R., Zhou, X., Adunyah, S. E., Matusik, R. J., Wang, X. & Chen, Z., Oct 2023, In: Molecular Oncology. 17, 10, p. 2126-2146 21 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Allosteric interactions prime androgen receptor dimerization and activation
Wasmuth, E. V., Vanden Broeck, A., LaClair, J. R., Hoover, E. A., Lawrence, K. E., Paknejad, N., Pappas, K., Matthies, D., Wang, B., Feng, W., Watson, P. A., Zinder, J. C., Karthaus, W. R., de la Cruz, M. J., Hite, R. K., Manova-Todorova, K., Yu, Z., Weintraub, S. T., Klinge, S. & Sawyers, C. L., Jun 2 2022, In: Molecular Cell. 82, 11, p. 2021-2031.e5 16 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations