Research output per year
Research output per year
Personal profile
Professional Information
Lab Overview
My research efforts span the basic and the translational sciences. The work in our lab focuses on understanding the process of prostate and renal carcinogenesis and assessing novel therapeutic regimens for the treatment of urological cancers. My research interests include mechanisms of resistance to tyrosine kinase inhibitors and androgen deprivation therapy, as well as development of novel and repurposing of existing pharmacological agents.
Research interests
- Resistance to multitargeted receptor tyrosine kinase inhibitors in renal cell carcinoma.
- Resistance to androgen deprivation therapy in prostate cancer.
- Non-NAD-like PARP-1 inhibitors as novel therapeutic agents for the treatment of genitourinary cancers.
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Dive into the research topics where Vladimir M. Kolenko is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Targeting NPC1 in Renal Cell Carcinoma
Fazliyeva, R., Makhov, P., Uzzo, R. G. & Kolenko, V. M., Feb 2024, In: Cancers. 16, 3, 517.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Examining the Effect of PARP-1 Inhibitors on Transcriptional Activity of Androgen Receptor in Prostate Cancer Cells
Makhov, P., Fazliyeva, R., Tufano, A., Uzzo, R. G. & Kolenko, V. M., 2023, Methods in Molecular Biology. Humana Press Inc., Vol. 2609. p. 329-335 7 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
3 Scopus citations -
Acetyl-CoA Counteracts the Inhibitory Effect of Antiandrogens on Androgen Receptor Signaling in Prostate Cancer Cells
Makhov, P., Fazliyeva, R., Tufano, A., Uzzo, R. G., Cai, K. Q., Serebriiskii, I., Snyder, N. W., Andrews, A. J. & Kolenko, V. M., Dec 2022, In: Cancers. 14, 23, 5900.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Histone-dependent PARP-1 inhibitors: A novel therapeutic modality for the treatment of prostate and renal cancers
Makhov, P., Uzzo, R. G., Tulin, A. V. & Kolenko, V. M., Jun 2021, In: Urologic Oncology: Seminars and Original Investigations. 39, 6, p. 312-315 4 p.Research output: Contribution to journal › Review article › peer-review
Open Access11 Scopus citations -
Poly(ADP)-ribosylation inhibition: A promising approach for clear cell renal cell carcinoma therapy
Karpova, Y., Guo, D., Makhov, P., Haines, A. M., Markov, D. A., Kolenko, V. & Tulin, A. V., Sep 3 2021, In: Cancers. 13, 19, 4973.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations
Press/Media
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Data from Fox Chase Cancer Center Broaden Understanding of Carcinomas (Targeting NPC1 in Renal Cell Carcinoma)
Kolenko, V. M., Uzzo, R. G. & Makhov, P. B.
02/9/24
1 item of Media coverage
Press/Media
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Researchers from Fox Chase Cancer Center Publish New Studies and Findings in the Area of Prostate Cancer (Acetyl-CoA Counteracts the Inhibitory Effect of Antiandrogens on Androgen Receptor Signaling in Prostate Cancer Cells)
Kolenko, V. M., Uzzo, R. G. & Makhov, P. B.
12/23/22
1 item of Media coverage
Press/Media
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Fox Chase Cancer Center: Gene Editing Technology Harnessed to Identify New, Druggable Targets in Kidney Cancer
Kolenko, V. M. & Makhov, P. B.
11/6/20
1 item of Media coverage
Press/Media
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Fox Chase Researchers Find Novel Histone-Dependent PARP-1 Inhibitors More Effective at Treating Prostate and Renal Cancers
Makhov, P. B., Uzzo, R. G. & Kolenko, V. M.
08/31/20 → 09/1/20
2 items of Media coverage
Press/Media