Michael J. Hall

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Michael J. Hall, MD, MS

Professor, Chair, Department of Clinical Genetics, Program Leader, Cancer Prevention and Control, Director, Gastrointestinal Risk Assessment, NCCN, Genetic Colorectal/Colorectal Cancer Screening Panel Member

 https://orcid.org/0000-0003-4515-3409
1996 …2026

Research activity per year

Personal profile

Personal profile

Treatment Philosophy

I am a GI oncologist and a clinical cancer geneticist, and I have found over the years that my strongest skills are in helping my patients and their families to understand the complicated risks of cancer screening, surgery and treatment, to weigh the different options for treatment, and finally to develop a plan that is both in line with cutting edge research but also with their personal needs and preferences for their health and their lives. In cancer medicine, there is no longer a one size fits all approach, and in my practice I strive to build on my patients’ unique strengths and to further bring the multi-faceted expertise of my colleagues at Fox Chase and my colleagues nationally to offer each of my patients the best care I possibly can.

 

Research interests

Since 1991, the Risk Assessment Program has received strong support from its clinical and research participants and referring providers. Over 11,000 patients have joined RAP’s registry and donated epidemiologic data and a biospecimen (~8,000 blood donations). This valuable resource is available to FCCC investigators and the wider genetics community and has generated significant grant support, publications, and presentations at national/international venues. RAP, the research component of the Department of Clinical Genetics, is part of the FCCC Cancer Prevention and Control (CPC) program. RAP maintains close collaborations with clinical, behavioral, and laboratory scientists with research interests in genetic risk and cancer prevention. RAP administers studies of the biological, genetic and environmental factors that influence cancer risk. RAP has established a unique registry of family data, blood, and tissue samples that is used to study the genetic basis of cancer. Our work is supported by funding from governmental, foundation, industry, and philanthropic sources and has contributed significantly to the field.

My group’s research is in three areas related to GI genetic risk and risk assessment. My primary syndrome of expertise and study is Lynch syndrome, but I have also performed research among all high risk GI patients, patients with hereditary breast/ovarian cancer and BRCA1/2 mutations, hereditary pancreatic cancer, high risk renal cell cancers, and others:

  1. Characterization of genetic risks associated with germline genes and molecular genetic changes that increase cancer risks including gene discovery. Our research has included studies to characterize the spectrum of cancer risk associated with hereditary risk genes, studies in high risk patients recruited through our Risk Assessment Program database to identify new cancer risks, and characterization of molecular risks in high risk patients such as TMB, MSI, and others.
  2. Communication of genetic risks to patients, whether related to novel tests (tumor genomic testing), novel pathways for communication of genetic risk information (telephone, online, etc), and supports for communication.
  3. Disparities associated with risk assessment and clinical genetics testing awareness, access, utilization, communication of results in families, and use of preventive screening.

Research interests

Dr. Hall's profile on Fox Chase website

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  • A history of the collaborative group of the Americas on inherited gastrointestinal cancer (CGA-IGC): 1995-2025

    Dudley, B., Boman, B. M., Greenblatt, M. S., Erdman, S. H., Wise, P. E., Brand, R. E., Burke, C. A., Guillem, J. G., Hall, M. J., Hampel, H., Heald, B., Kalady, M. F., Katona, B. W., Kupfer, S. S., Lynch, P. M., Patel, S. G., Stanich, P. P., Stoffel, E. M., Yurgelun, M. B. & Church, J., Mar 2026, In: Familial Cancer. 25, 1, p. 15 15.

    Research output: Contribution to journal › Article › peer-review

  • Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial

    D’Alise, A. M., Willis, J., Duzagac, F., Hall, M. J., Cruz-Correa, M., Idos, G. E., Thirumurthi, S., Ballester, V., Leoni, G., Garzia, I., Antonucci, L., De Marco, L., Micarelli, E., Deng, N., Seclì, L., Gogov, S., Dong, W., Jack Lee, J., Bowen, C. M. & Vornik, L. A. & 9 others, Garcia-Gonzalez, A., Reyes-Uribe, L., Richmond, E., Umar, A., Brown, P. H., Sinha, K. M., Rodriguez, L. M., Scarselli, E. & Vilar, E., Jan 16 2026, (E-pub ahead of print) In: Nature Medicine.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Targeted Prostate Cancer Screening in Carriers of BRCA1 or BRCA2 Pathogenic Germline Variants Detects Clinically Relevant Disease: 5-year Results from the IMPACT Study

    Bancroft, E. K., Page, E. C., McHugh, J., Thomas, S., Taylor, N., Pope, J., Evans, D. G., Rothwell, J., Grindedal, E. M., Maehle, L., James, P., McKinley, J., Mascarenhas, L., Side, L., Thomas, T., van Leerdam, M. E., van Asperen, C. J., Kiemeney, L. A. L. M., Ringelberg, J. & Vlaming, M. & 99 others, Rønlund, K., Osther, P. J. S., Helfand, B. T., Hutten, C. G., Oldenburg, R. A., Cybulski, C., Wokolorczyk, D., Ong, K. R., Huber, C., Salinas, M., Feliubadaló, L., Oosterwijk, J. C., van Zelst-Stams, W. A. G., Cook, J., Rosario, D. J., Maxwell, K., Powers, J., Buys, S., Lyman, J., Ausems, M. G. E. M., Schmutzler, R. K., Rhiem, K., Izatt, L., Tripathi, V., Teixeira, M. R., Cardoso, M., Foulkes, W. D., Aprikian, A., Davidson, R., Longmuir, M., Ruijs, M. W. G., Blom, E. W., van Engelen, K., Williams, R., Andrews, L., Murphy, D. G., Saya, S., Halliday, D., Walker, L., Liljegren, A., Carlsson, S., Azzabi, A., Jobson, I., Snape, K., Gowie, M., Harris, M., Tischkowitz, M., Taylor, A., Kirk, J., Susman, R., Chen-Shtoyerman, R., Spigelman, A., Pachter, N., Ahmed, M., Cajal, T. R. Y., Krajc, M., Cleaver, R., Cruellas, M., Perez-Ballestero, E., Brady, A. F., Gallagher, D., Donaldson, A., Barwell, J., Nicolai, N., Friedman, E., Hall, M. J., Greenhalgh, L., Murthy, V., Copakova, L., McGrath, J. S., Cooke, P., Arun, B., Myhill, K., Hogben, M., Hussain, S., Aaronson, N. K., Ardern-Jones, A., Bangma, C. H., Castro, E., Dearnaley, D., Eccles, D. M., Tricker, K., Falconer, A., Gronberg, H., Hamdy, F. C., Khoo, V., Lilja, H., Lindeman, G. J., Lubinski, J., Axcrona, K., Mikropoulos, C., Mitra, A., Offman, J., Rennert, G., Suri, M., Dudderidge, T., Brook, M. N., Kote-Jarai, Z. & Eeles, R. A., 2026, (Accepted/In press) In: European Urology.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Development and user testing of gene pilot: an electronic health decision support tool for Black cancer patients about tumor genomic profile testing

    Bass, S. B., Chertock, Y., Brajuha, J., Kelly, P. J. A., Rotaru, A. M., D’Avanzo, P., Hoadley, A., Luck, C., Singley, K. & Hall, M. J., 2025, In: Frontiers in Communication. 10, 1505456.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Disparities in fertility preservation discussions among sexual and gender minority cancer patients and their cancer care providers

    Wilson-Shabazz, I. N., Wheldon, C. W., Hall, M. J. & Bass, S. B., 2025, In: Journal of Psychosocial Oncology. 43, 3, p. 319-336 18 p.

    Research output: Contribution to journal › Article › peer-review

    3 Scopus citations
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