Personal profile
Research interests
The long-term focus of our research program is the identification and characterization of proteins and pathways which play a role in regulation of vascular inflammation, with a current focus on the role of endogenous anti-inflammatory cytokines in this process. We have two distinct, but related areas of investigation: 1- inhibition of vascular occlusive diseases such as atherosclerosis, restenosis, and allograft vasculopathy, and; 2- promotion of angiogenesis to treat peripheral vascular disease. Currently, we are focusing on an endogenous anti-inflammatory cytokine termed IL-19 which: regulates macrophage polarity, macrophage and smooth muscle cell cholesterol homeostasis, smooth muscle and endothelial cell proliferation, and decreases inflammatory mRNA stability, suggesting that this cytokine may represent a therapeutic modality to treat vascular inflammatory diseases.
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Collaborations and top research areas from the last five years
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Editorial: Exploring lymphatic vasculature's role in cardiovascular and metabolic diseases
Liu, X., Yang, X. & Autieri, M. V., 2026, In: Frontiers in Cardiovascular Medicine. 13, p. 1805707 1805707.Research output: Contribution to journal › Editorial
Open Access -
Senescence: An Overlooked VSMC Phenotype and Therapeutic Opportunity?
Herman, A. B., Gresova, K., Maragkakis, M. & Autieri, M. V., Jan 1 2026, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 46, 1, p. 119-131 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model
Saaoud, F., Liu, L., Xu, K., Lu, Y., Shao, Y., Ben Issa, M., Jiang, X., Wang, X., Liu, X., Autieri, M., Wu, S., Wei, J., Yu, J., Bouchareb, R., Gillespie, A., Luo, J. J., Martinez, L., Vazquez-Padron, R., Sun, J. & Zhao, H. & 3 others, , May 2025, In: Journal of Alzheimer's Disease. 105, 2, p. 550-572 23 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
IL-19 Is a Novel Lymphangiocrine Factor Inducing Lymphangiogenesis and Lymphatic Junctional Regulation
Peluzzo, A. M., St Paul, A., Corbett, C. B., Kelemen, S. E., Fossati, S., Liu, X. & Autieri, M. V., Jul 2025, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 45, 7, p. 1244-1265 22 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A neuro-lymphatic communication guides lymphatic development by CXCL12 and CXCR4 signaling
Hoang Do, L. N., Delgado, E., Lim, C. G., Bkhache, M., Peluzzo, A. M., Hua, Y., Oza, M., Mohsin, S., Chen, H., Autieri, M. V., Kim, S. & Liu, X., Nov 2024, In: Development (Cambridge). 151, 22, dev202901.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations
Press/Media
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Studies from Temple University Provide New Data on Hypertension (Mitochondrial Fission Inhibition Protects Against Hypertension Induced By Angiotensin Ii)
04/8/24
1 item of Media coverage
Press/Media