The Campbell lab has a longstanding interest in the mechanisms by which an assortment of germline-encoded receptors on the surface of human natural killer (NK) cells control their cytotoxic response toward tumor cells and to determine how that information might be exploited therapeutically to benefit cancer patients. In the course of over 25 years of independent research at Fox Chase Cancer Center, the group has gained extensive expertise in the culture and genetic manipulation of primary human NK cells and NK cell lines, as well as techniques in protein biochemistry, signaling, and molecular biology to study these intriguing innate immune cells. More recently, the team has focused extensively on clinical and translational research, in which they have studied the phenotype and function of NK, T, and myeloid cells in patients with various cancers and the mechanisms of action of several immunotherapeutic agents that exploit NK cell function in cancer patients.