Research output per year
Research output per year
Search results
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2025
Modeling Malignant Mesothelioma in Genetically Engineered Mice
Kadariya, Y., Sementino, E., Hua, X., Kappes, D. J. & Testa, J. R., Jan 2025, In: Current Protocols. 5, 1, p. e70086 e70086.Research output: Contribution to journal › Article › peer-review
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Tumor infiltrating T-cells and loss of expression of SWI/SNF genes in varying stages of clear cell renal cell carcinoma
Hrizat, A. S., Lin, R., Eberle-Singh, J., O'Neill, R., Xia, Y., Testa, J. R., Uzzo, R., McCue, P. A., Yang, H. & Li, L., Feb 1 2025, In: Pathology Research and Practice. 266, p. 155774 1 p.Research output: Contribution to journal › Article › peer-review
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Tumor infiltrating T-cells and loss of expression of SWI/SNF genes in varying stages of clear cell renal cell carcinoma
Hrizat, A. S., Lin, R., Eberle-Singh, J., O'Neill, R., Xia, Y., Testa, J. R., Uzzo, R., McCue, P. A., Yang, H. & Li, L., Feb 2025, In: Pathology Research and Practice. 266, p. 155774Research output: Contribution to journal › Article › peer-review
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2024
Acute myeloid leukemia with a novel AKAP9::PDGFRA fusion transformed from essential thrombocythemia: A case report and mini review
Sahin, Y., Pei, J., Baldwin, D. A., Mansoor, N., Koslosky, L., Abdelmessieh, P., Wang, Y. L., Nejati, R. & Testa, J. R., Jan 2024, In: Leukemia Research Reports. 21, p. 100465 100465.Research output: Contribution to journal › Article › peer-review
Open Access -
Alterations of the AKT Pathway in Sporadic Human Tumors, Inherited Susceptibility to Cancer, and Overgrowth Syndromes
Menges, C. W., Hassan, D., Cheung, M., Bellacosa, A. & Testa, J. R., Aug 28 2024, (E-pub ahead of print) In: Current Topics in Microbiology and Immunology.Research output: Contribution to journal › Article › peer-review
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Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment
Kadariya, Y., Sementino, E., Ruan, M., Cheung, M., Hadikhani, P., Osmanbeyoglu, H. U., Klein-Szanto, A. J., Cai, K. & Testa, J. R., Apr 2024, In: Cancer Research Communications. 4, 4, p. 1004-1015 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Spatial Landscape of Malignant Pleural and Peritoneal Mesothelioma Tumor Immune Microenvironments
Ma, X., Lembersky, D., Kim, E. S., Becich, M. J., Testa, J. R., Bruno, T. C. & Osmanbeyoglu, H. U., Aug 1 2024, In: Cancer Research Communications. 4, 8, p. 2133-2146 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma
Testa, J. R., Kadariya, Y. & Friedberg, J. S., May 23 2024, In: Oncoscience. 11, p. 53-57 5 p.Research output: Contribution to journal › Article › peer-review
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2023
Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities
Krais, J. J., Glass, D. J., Chudoba, I., Wang, Y., Feng, W., Simpson, D., Patel, P., Liu, Z., Neumann-Domer, R., Betsch, R. G., Bernhardy, A. J., Bradbury, A. M., Conger, J., Yueh, W. T., Nacson, J., Pomerantz, R. T., Gupta, G. P., Testa, J. R. & Johnson, N., Dec 2023, In: Nature Communications. 14, 1, p. 7714 7714.Research output: Contribution to journal › Article › peer-review
Open Access -
Isochromosome 7p, i(7)(p10): A rare AML, myelodysplasia-related entity
Nejati, R., Neumann-Domer, R., Liu, Z., Koslosky, L., Neumann-Domer, E., Pei, J., Wang, Y. L. & Testa, J. R., Jan 2023, In: Leukemia Research Reports. 20, p. 100387 100387.Research output: Contribution to journal › Article › peer-review
Open Access -
Multiple Genomic Alterations, Including a Novel AFF4::IRF1 Fusion Gene, in a Treatment-Refractory Blastic Plasmacytoid Dendritic-Cell Neoplasm: A Case Report and Literature Review
Sahin, Y., Wang, Y. L., Pei, J., Mansoor, N., Styler, M., Testa, J. R. & Nejati, R., Nov 25 2023, In: International Journal of Molecular Sciences. 25, 1, 305.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma
Langbein, L. E., El Hajjar, R., He, S., Sementino, E., Zhong, Z., Jiang, W., Leiby, B. E., Li, L., Uzzo, R. G., Testa, J. R. & Yang, H., Oct 28 2022, In: Cancer Letters. 547, p. 215885 215885.Research output: Contribution to journal › Article › peer-review
Open Access -
Correction to: Thymine DNA glycosylase as a novel target for melanoma (Oncogene, (2019), 38, 19, (3710-3728), 10.1038/s41388-018-0640-2)
Mancuso, P., Tricarico, R., Bhattacharjee, V., Cosentino, L., Kadariya, Y., Jelinek, J., Nicolas, E., Einarson, M., Beeharry, N., Devarajan, K., Katz, R. A., Dorjsuren, D. G., Sun, H., Simeonov, A., Giordano, A., Testa, J. R., Davidson, G., Davidson, I., Larue, L. & Sobol, R. W. & 2 others, , May 2022, In: Oncogene. 41, 23, p. 3300-3301 2 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Data supporting the roles of BAP1, STING, and IFN-β in ISGF3 activation in ccRCC
Langbein, L. E., Sementino, E., Zhong, Z., Jiang, W., Li, L., Testa, J. R. & Yang, H., Dec 2022, In: Data in Brief. 45, p. 108743 108743.Research output: Contribution to journal › Article › peer-review
Open Access -
Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
Sementino, E., Kadariya, Y., Cheung, M., Menges, C. W., Tan, Y., Kukuyan, A. M., Shrestha, U., Karchugina, S., Cai, K. Q., Peri, S., Duncan, J. S., Chernoff, J. & Testa, J. R., May 2022, In: Molecular Cancer Research. 20, 5, p. 699-711 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inflammation as a chemoprevention target in asbestos-induced malignant mesothelioma
Kadariya, Y., Sementino, E., Shrestha, U., Gorman, G., White, J. M., Ross, E. A., Clapper, M. L., Neamati, N., Miller, M. S. & Testa, J. R., Dec 1 2022, In: Carcinogenesis. 43, 12, p. 1137-1148 12 p.Research output: Contribution to journal › Article › peer-review
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Isolated BAP1 Genomic Alteration in Malignant Pleural Mesothelioma Predicts Distinct Immunogenicity with Implications for Immunotherapeutic Response
Osmanbeyoglu, H. U., Palmer, D., Sagan, A., Sementino, E., Becich, M. J. & Testa, J. R., Nov 2022, In: Cancers. 14, 22, 5626.Research output: Contribution to journal › Article › peer-review
Open Access -
Mesothelioma Mouse Models with Mixed Genomic States of Chromosome and Microsatellite Instability
Song, Y., Baxter, S. S., Dai, L., Sanders, C., Burkett, S., Baugher, R. N., Mellott, S. D., Young, T. B., Lawhorn, H. E., Difilippantonio, S., Karim, B., Kadariya, Y., Pinto, L. A., Testa, J. R. & Shoemaker, R. H., May 24 2022, In: Cancers. 14, 13, 3108.Research output: Contribution to journal › Article › peer-review
Open Access -
Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells
Pietrofesa, R. A., Chatterjee, S., Kadariya, Y., Testa, J. R., Albelda, S. M. & Christofidou-Solomidou, M., Aug 3 2022, In: International Journal of Molecular Sciences. 23, 17, 10085.Research output: Contribution to journal › Article › peer-review
Open Access -
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells
Kurimchak, A. M., Herrera-Montávez, C., Montserrat-Sangrà, S., Araiza-Olivera, D., Hu, J., Neumann-Domer, R., Kuruvilla, M., Bellacosa, A., Testa, J. R., Jin, J. & Duncan, J. S., Aug 30 2022, In: Science Signaling. 15, 749, p. eabn2707 eabn2707.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase
Zhao, Z., Fowle, H., Valentine, H., Liu, Z., Tan, Y., Pei, J., Badal, S., Testa, J. R. & Grana, X., Mar 2021, In: Prostate Cancer and Prostatic Diseases. 24, 1, p. 233-243 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Kinetic characterization of ASXL1/2-mediated allosteric regulation of the BAP1 deubiquitinase
Peng, H., Cassel, J., McCracken, D. S., Prokop, J. W., Sementino, E., Cheung, M., Collop, P. R., Polo, A., Joshi, S., Mandell, J. P., Ayyanathan, K., Hinds, D., Malkowicz, S. B., Harbour, J. W., Bowcock, A. M., Salvino, J., Kennedy, E. J., Testa, J. R. & Rauscher, F. J., Jul 2021, In: Molecular Cancer Research. 19, 7, p. 1099-1112 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel LRRK2 mutations and other rare, non-BAP1-related candidate tumor predisposition gene variants in high-risk cancer families with mesothelioma and other tumors
Cheung, M., Kadariya, Y., Sementino, E., Hall, M. J., Cozzi, I., Ascoli, V., Ohar, J. A. & Testa, J. R., Sep 15 2021, In: Human Molecular Genetics. 30, 18, p. 1750-1761 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Replication gaps underlie BRCA deficiency and therapy response
Panzarino, N. J., Cong, K., Peng, M., Mosqueda, M., Nayak, S. U., Bond, S. M., Calvo, J. A., Doshi, M. B., Bere, M., Ou, J., Deng, B., Zhu, L. J., Johnson, N., Cantor, S. B., Testa, J. R. & Krais, J. J., Mar 1 2021, In: Cancer Research. 81, 5, p. 1388-1397 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma
Tan, Y., Sementino, E., Cheung, M., Peri, S., Menges, C. W., Kukuyan, A. M., Zhang, T., Khazak, V., Fox, L. A., Ross, E. A., Ramanathan, S., Jhanwar, S. C., Flores, R. M., Balachandran, S. & Testa, J. R., Feb 15 2021, In: Clinical Cancer Research. 27, 4, p. 1200-1213 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Application of chromosome microarray analysis for the differential diagnosis of low-grade renal cell carcinoma with clear cell and papillary features
Pei, J., Al-Saleem, T., Uzzo, R. G., Dulaimi, E., Testa, J. R. & Wei, S., Feb 1 2020, In: Applied Immunohistochemistry and Molecular Morphology. 28, 2, p. 123-129 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
BRCA1 Mutational Complementation Induces Synthetic Viability
Nacson, J., Di Marcantonio, D., Wang, Y., Bernhardy, A. J., Clausen, E., Hua, X., Cai, K. Q., Martinez, E., Feng, W., Callén, E., Wu, W., Gupta, G. P., Testa, J. R., Nussenzweig, A., Sykes, S. M. & Johnson, N., Jun 4 2020, In: Molecular Cell. 78, 5, p. 951-959.e6Research output: Contribution to journal › Article › peer-review
Open Access -
Hypomorphic mTOR downregulates CDK6 and Delays Thymic Pre-T LBL tumorigenesis
Gary, J. M., Simmons, J. K., Xu, J., Zhang, S., Peat, T. J., Watson, N., Gamache, B. J., Zhang, K., Kovalchuk, A. L., Michalowski, A. M., Chen, J. Q., Thaiwong, T., Kiupel, M., Gaikwad, S., Etienne, M., Simpson, R. M., Dubois, W., Testa, J. R. & Mock, B. A., Oct 1 2020, In: Molecular Cancer Therapeutics. 19, 10, p. 2221-2232 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Monosomy of Chromosome 9 Is Associated With Higher Grade, Advanced Stage, and Adverse Outcome in Clear-cell Renal Cell Carcinoma
Nejati, R., Wei, S., Uzzo, R. G., Poureghbali, S., Pei, J., Talarchek, J. N., Ruth, K., Dulaimi, E., Kutikov, A., Testa, J. R. & Al-Saleem, T., Feb 2020, In: Clinical Genitourinary Cancer. 18, 1, p. 56-61 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Overall tumor genomic instability: an important predictor of recurrence-free survival in patients with localized clear cell renal cell carcinoma
Correa, A. F., Ruth, K. J., Al-Saleem, T., Pei, J., Dulaimi, E., Kister, D., Collins, M., Abbosh, P. H., Slifker, M. J., Ross, E., Uzzo, R. G. & Testa, J. R., Apr 3 2020, In: Cancer Biology and Therapy. 21, 5, p. 424-431 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis
Tan, Y., Sementino, E., Liu, Z., Cai, K. Q. & Testa, J. R., Aug 28 2020, In: Scientific Reports. 10, 1, p. 15837 15837.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Clinical application of RNA sequencing in sarcoma diagnosis: An institutional experience
Pei, J., Zhao, X., Patchefsky, A. S., Flieder, D. B., Talarchek, J. N., Testa, J. R. & Wei, S., Jun 1 2019, In: Medicine. 98, 25, p. e16031Research output: Contribution to journal › Article › peer-review
Open Access -
Detecting MYB and MYBL1 fusion genes in tracheobronchial adenoid cystic carcinoma by targeted RNA-sequencing
Pei, J., Flieder, D. B., Patchefsky, A., Talarchek, J. N., Cooper, H. S., Testa, J. R. & Wei, S., Oct 1 2019, In: Modern Pathology. 32, 10, p. 1416-1420 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inactivation of BAP1 cooperates with losses of NF2 and CDKN2A to drive the development of pleural malignant mesothelioma in conditional mouse models
Kukuyan, A. M., Sementino, E., Kadariya, Y., Menges, C. W., Cheung, M., Tan, Y., Cai, K. Q., Slifker, M. J., Peri, S., Klein-Szanto, A. J., Rauscher, F. J. & Testa, J. R., Aug 15 2019, In: Cancer Research. 79, 16, p. 4113-4123 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma
Pei, J., Cooper, H., Flieder, D. B., Talarchek, J. N., Al-Saleem, T., Uzzo, R. G., Dulaimi, E., Patchefsky, A. S., Testa, J. R. & Wei, S., May 1 2019, In: Modern Pathology. 32, 5, p. 710-716 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth
Cai, W., Su, L., Liao, L., Liu, Z. Z., Langbein, L., Dulaimi, E., Testa, J. R., Uzzo, R. G., Zhong, Z., Jiang, W., Yan, Q., Zhang, Q. & Yang, H., Dec 1 2019, In: Nature Communications. 10, 1, p. 5800 5800.Research output: Contribution to journal › Article › peer-review
Open Access -
RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance
Rao, S., Peri, S., Hoffmann, J., Cai, K., Harris, B., Rhodes, M., Connolly, D. C., Testa, J. R. & Wiest, D. L., Oct 1 2019, In: PLoS ONE. 14, 10, p. e0222392 e0222392.Research output: Contribution to journal › Article › peer-review
Open Access -
Thymine DNA glycosylase as a novel target for melanoma
Mancuso, P., Tricarico, R., Bhattacharjee, V., Cosentino, L., Kadariya, Y., Jelinek, J., Nicolas, E., Einarson, M., Beeharry, N., Devarajan, K., Katz, R. A., Dorjsuren, D. G., Sun, H., Simeonov, A., Giordano, A., Testa, J. R., Davidson, G., Davidson, I., Larue, L. & Sobol, R. W. & 2 others, , Apr 2019, In: Oncogene. 38, 19, p. 3710-3728 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
Nacson, J., Krais, J. J., Bernhardy, A. J., Clausen, E., Feng, W., Wang, Y., Nicolas, E., Cai, K. Q., Tricarico, R., Hua, X., DiMarcantonio, D., Martinez, E., Zong, D., Handorf, E., Bellacosa, A., Testa, J. R., Nussenzweig, A., Gupta, G. P., Sykes, S. M. & Johnson, N., Sep 25 2018, In: Cell Reports. 24, 13, p. 3513-3527.e7Research output: Contribution to journal › Article › peer-review
Open Access -
Familial and somatic BAP1 mutations inactivate ASXL1/2-mediated allosteric regulation of BAP1 deubiquitinase by targeting multiple independent domains
Peng, H., Prokop, J. W., Karar, J., Park, K., Harbour, J. W., Bowcock, A. M., Malkowicz, S. B., Cheung, M., Testa, J. R. & Rauscher, F. J., Mar 1 2018, In: Cancer Research. 78, 5, p. 1200-1213 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
Sementino, E., Menges, C. W., Kadariya, Y., Peri, S., Xu, J., Liu, Z., Wilkes, R. G., Cai, K. Q., Rauscher, F. J., Klein-Szanto, A. J. & Testa, J. R., Nov 2018, In: Journal of Cellular Physiology. 233, 11, p. 8952-8961 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Malignant Mesothelioma
De Rienzo, A. & Testa, J. R., 2018, In: Atlas of Genetics and Cytogenetics in Oncology and Haematology. 22, 9, p. 403-406 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Multiple tumor suppressors regulate a hif-dependent negative feedback loop via ISGF3 in human clear cell renal cancer
Liao, L., Liu, Z. Z., Langbein, L., Cai, W., Cho, E. A., Na, J., Niu, X., Jiang, W., Zhong, Z., Cai, W. L., Jagannathan, G., Dulaimi, E., Testa, J. R., Uzzo, R. G., Wang, Y., Stark, G. R., Sun, J., Peiper, S., Xu, Y. & Yan, Q. & 1 others, , Oct 2018, In: eLife. 7, e37925.Research output: Contribution to journal › Article › peer-review
Open Access -
The correlation between gain of chromosome 8q and survival in patients with clear and papillary renal cell carcinoma
Mehrazin, R., Dulaimi, E., Uzzo, R. G., Devarjan, K., Pei, J., Smaldone, M. C., Kutikov, A., Testa, J. R. & Al-Saleem, T., Jan 1 2018, In: Therapeutic Advances in Urology. 10, 1, p. 3-10 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Haploinsufficiency in tumor predisposition syndromes: Altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation
Peri, S., Caretti, E., Tricarico, R., Devarajan, K., Cheung, M., Sementino, E., Menges, C. W., Nicolas, E., Vanderveer, L. A., Howard, S., Conrad, P., Crowell, J. A., Campbell, K. S., Ross, E. A., Godwin, A. K., Yeung, A. T., Clapper, M. L., Uzzo, R. G., Henske, E. P. & Ricketts, C. J. & 6 others, , 2017, In: Oncotarget. 8, 11, p. 17628-17642 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma
Jiang, W., Dulaimi, E., Devarajan, K., Parsons, T., Wang, Q., O'Neill, R., Solomides, C., Peiper, S. C., Testa, J. R., Uzzo, R. & Yang, H., May 6 2017, In: Oncotarget. 8, 23, p. 37423-37434 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity
Tan, Y., Sementino, E., Testa, J. R. & Chernoff, J., 2017, In: American Journal of Cancer Research. 7, 8, p. 1724-1737 14 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling
Tan, Y., Sementino, E., Xu, J., Pei, J., Liu, Z., Ito, T. K., Cai, K. Q., Peri, S., Klein-Szanto, A. J. P., Wiest, D. L. & Testa, J. R., 2017, In: Oncotarget. 8, 9, p. 14941-14956 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
Alfred G. Knudson (1922-2016) Obituary
Bellacosa, A., Chernoff, J. & Testa, J., Aug 11 2016, In: Cell. 166, 4, p. 785-786 2 p.Research output: Contribution to journal › Article › peer-review
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Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts
Tan, Y., Xin, X., Coffey, F. J., Wiest, D. L., Dong, L. Q. & Testa, J. R., May 1 2016, In: Journal of Cellular Physiology. 231, 5, p. 1142-1150 9 p.Research output: Contribution to journal › Article › peer-review
Open Access