Research output per year
Research output per year
Personal profile
Research interests
Peripheral neuropathy and chronic pain are a common side effect of chemotherapy treatment for which there are no available treatments.
The Gómez-Deza Lab aims to understand how neurons are damaged in response to chemotherapy. However, our research is widely applicable to other neurodegenerative conditions such as glaucoma, traumatic brain injury (TBI) or Amyotrophic Lateral Sclerosis (ALS).
To do this, we employ a wide range of molecular and biochemical techniques, including iPSC differentiation into human neurons, whole genome CRISPR interference screens, RNAseq, CRISPR knock-ins/ knock-outs, and advanced microscopy.
The lab has a strong clinical focus. We are deeply interested in uncovering new molecular mechanisms that drive axon degeneration and neuron death to develop novel therapeutic strategies.
Our mission is also to educate and train the next generation of scientists by fostering a safe, innovative, fun and diverse environment that empowers individuals to reach their full potential. We value mental well-being, maintain a healthy work-life balance, and welcome everyone to our team.
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Collaborations and top research areas from the last five years
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DLK-dependent axonal mitochondrial fission drives degeneration after axotomy
Gómez-Deza, J., Nebiyou, M., Alkaslasi, M. R., Nadal-Nicolás, F. M., Somasundaram, P., Slavutsky, A. L., Li, W., Ward, M. E., Watkins, T. A. & Le Pichon, C. E., Dec 30 2024, In: Nature Communications. 15, 1, p. 10806 10806.Research output: Contribution to journal › Article › peer-review
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Local production of reactive oxygen species drives vincristine-induced axon degeneration
Gomez-Deza, J., Slavutsky, A. L., Nebiyou, M. & Le Pichon, C. E., Dec 8 2023, In: Cell Death & Disease. 14, 12, p. 807 807.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity
Lee, Y.-B., Baskaran, P., Gomez-Deza, J., Chen, H.-J., Nishimura, A. L., Smith, B. N., Troakes, C., Adachi, Y., Stepto, A., Petrucelli, L., Gallo, J.-M., Hirth, F., Rogelj, B., Guthrie, S. & Shaw, C. E., Apr 26 2021, In: Human Molecular Genetics. 30, 3-4, p. 318-320 3 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Amyotrophic Lateral Sclerosis and Other TDP-43 Proteinopathies
Gomez-Deza, J. & Shaw, C. E., Jan 1 2018, The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms. Elsevier, p. 99-115 17 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Scopus citations -
C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity
Lee, Y.-B., Baskaran, P., Gomez-Deza, J., Chen, H.-J., Nishimura, A. L., Smith, B. N., Troakes, C., Adachi, Y., Stepto, A., Petrucelli, L., Gallo, J.-M., Hirth, F., Rogelj, B., Guthrie, S. & Shaw, C. E., Dec 15 2017, In: Human Molecular Genetics. 26, 24, p. 4765-4777 13 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations