Israel Canadas
Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
20082025

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  • 2024

    Autophagy-driven regulation of cisplatin response in human cancers: Exploring molecular and cell death dynamics

    Yang, Y., Liu, L., Tian, Y., Gu, M., Wang, Y., Ashrafizadeh, M., Reza Aref, A., Cañadas, I., Klionsky, D. J., Goel, A., Reiter, R. J., Wang, Y., Tambuwala, M. & Zou, J., Apr 10 2024, In: Cancer Letters. 587, p. 216659 216659.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    56 Scopus citations
  • N-MYC impairs innate immune signaling in high-grade serous ovarian carcinoma

    Miranda, A., Pattnaik, S., Hamilton, P. T., Fuss, M. A., Kalaria, S., Laumont, C. M., Smazynski, J., Mesa, M., Banville, A., Jiang, X., Jenkins, R., Cañadas, I. & Nelson, B. H., May 2024, In: Science Advances. 10, 20, p. eadj5428 eadj5428.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    2 Scopus citations
  • RNA sensing induced by chromosome missegregation augments anti-tumor immunity

    Sasaki, N., Homme, M., Murayama, T., Osaki, T., Tenma, T., An, T., Takegami, Y., Tani, T., Gedeon, P. C., Kobayashi, Y., Cañadas, I., Barbie, D. A., Yao, R. & Kitajima, S., Dec 19 2024, (E-pub ahead of print) In: Molecular Cell.

    Research output: Contribution to journalArticlepeer-review

  • Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer

    Murayama, T., Nakayama, J., Jiang, X., Miyata, K., Morris, A. D., Cai, K. Q., Prasad, R. M., Ma, X., Efimov, A., Belani, N., Gerstein, E. R., Tan, Y., Zhou, Y., Kim, W., Maruyama, R., Campbell, K. S., Chen, L., Yang, Y., Balachandran, S. & Canadas, I., 2024, In: Cancer Discovery. 14, 3, p. 468-491 24 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    25 Scopus citations
  • Targeting TREX1 Induces Innate Immune Response in Drug-Resistant Small-Cell Lung Cancer

    Murayama, T., Mahadevan, N. R., Meador, C. B., Ivanova, E. V., Pan, Y., Knelson, E. H., Tani, T., Nakayama, J., Ma, X., Thai, T. C., Hung, Y. P., Kim, W., Watanabe, H., Cai, K. Q., Hata, A. N., Paweletz, C. P., Barbie, D. A. & Cañadas, I., Sep 1 2024, In: Cancer Research Communications. 4, 9, p. 2399-2414 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • 2023

    Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor-Positive Breast Cancer

    Hermida-Prado, F., Xie, Y., Sherman, S., Nagy, Z., Russo, D., Akhshi, T., Chu, Z., Feit, A., Campisi, M., Chen, M., Nardone, A., Guarducci, C., Lim, K., Font-Tello, A., Lee, I., García-Pedrero, J., Cañadas, I., Agudo, J., Huang, Y. & Sella, T. & 21 others, Jin, Q., Tayob, N., Mittendorf, E. A., Tolaney, S. M., Qiu, X., Long, H., Symmans, W. F., Jia-Ren, L., Santagata, S., Bedrosian, I., Yardley, D. A., Mayer, I. A., Richardson, E. T., Oliveira, G., Wu, C. J., Schuster, E. F., Dowsett, M., Welm, A. L., Barbie, D., Metzger, O. & Jeselsohn, R., Oct 1 2023, In: Cancer Research. 83, 19, p. 3284-3304 21 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4 Scopus citations
  • TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype

    Tricarico, R., Madzo, J., Scher, G., Cohen, M., Jelinek, J., Maegawa, S., Nagarathinam, R., Scher, C., Chang, W. C., Nicolas, E., Slifker, M., Zhou, Y., Devarajan, K., Cai, K. Q., Kwok, T., Nakajima, P., Xu, J., Mancuso, P., Doneddu, V. & Bagella, L. & 21 others, Williams, R., Balachandran, S., Maskalenko, N., Campbell, K., Ma, X., Cañadas, I., Viana-Errasti, J., Moreno, V., Valle, L., Grivennikov, S., Peshkova, I., Kurilenko, N., Mazitova, A., Koltsova, E., Lee, H., Walsh, M., Duttweiler, R., Whetstine, J. R., Yen, T. J., Issa, J. P. & Bellacosa, A., May 2023, In: Gastroenterology. 164, 6, p. 921-936.e1

    Research output: Contribution to journalArticlepeer-review

    Open Access
    14 Scopus citations
  • 2022

    Activation of Tumor-Cell STING Primes NK-Cell Therapy

    Knelson, E. H., Ivanova, E. V., Tarannum, M., Campisi, M., Lizotte, P. H., Booker, M. A., Ozgenc, I., Noureddine, M., Meisenheimer, B., Chen, M., Piel, B., Spicer, N., Obua, B., Messier, C. M., Shannon, E., Mahadevan, N. R., Tani, T., Schol, P. J., Lee-Hassett, A. M. & Zlota, A. & 29 others, Vo, H. V., Ha, M., Bertram, A. A., Han, S., Thai, T. C., Gustafson, C. E., Venugopal, K., Haggerty, T. J., Albertson, T. P., Hartley, A. V., Eser, P. O., Li, Z. H., Cañadas, I., Vivero, M., De Rienzo, A., Richards, W. G., Abu-Yousif, A. O., Appleman, V. A., Gregory, R. C., Parent, A., Lineberry, N., Smith, E. L., Jänne, P. A., Miret, J. J., Tolstorukov, M. Y., Romee, R., Paweletz, C. P., Bueno, R. & Barbie, D. A., Aug 2022, In: Cancer Immunology Research. 10, 8, p. 947-961 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    39 Scopus citations
  • MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer

    Yoshida, R., Saigi, M., Tani, T., Springer, B. F., Shibata, H., Kitajima, S., Mahadevan, N. R., Campisi, M., Kim, W., Kobayashi, Y., Thai, T. C., Haratani, K., Yamamoto, Y., Sundararaman, S. K., Knelson, E. H., Vajdi, A., Canadas, I., Uppaluri, R., Paweletz, C. P. & Miret, J. J. & 4 others, Lizotte, P. H., Gokhale, P. C., Jänne, P. A. & Barbie, D. A., Nov 1 2022, In: Cancer Research. 82, 21, p. 4079-4092 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    17 Scopus citations
  • 2021

    EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

    Morel, K. L., Sheahan, A. V., Burkhart, D. L., Baca, S. C., Boufaied, N., Liu, Y., Qiu, X., Cañadas, I., Roehle, K., Heckler, M., Calagua, C., Ye, H., Pantelidou, C., Galbo, P., Panja, S., Mitrofanova, A., Wilkinson, S., Whitlock, N. C., Trostel, S. Y. & Hamid, A. A. & 17 others, Kibel, A. S., Barbie, D. A., Choudhury, A. D., Pomerantz, M. M., Sweeney, C. J., Long, H. W., Einstein, D. J., Shapiro, G. I., Dougan, S. K., Sowalsky, A. G., He, H. H., Freedman, M. L., Balk, S. P., Loda, M., Labbé, D. P., Olson, B. M. & Ellis, L., Mar 2021, In: Nature Cancer. 2, 4, p. 444-456 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    152 Scopus citations
  • Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity

    Mahadevan, N. R., Knelson, E. H., Wolff, J. O., Vajdi, A., Saigí, M., Campisi, M., Hong, D., Thai, T. C., Piel, B., Han, S., Reinhold, B. B., Duke-Cohan, J. S., Poitras, M. J., Taus, L. J., Lizotte, P. H., Portell, A., Quadros, V., Santucci, A. D., Murayama, T. & Cañadas, I. & 23 others, Kitajima, S., Akitsu, A., Fridrikh, M., Watanabe, H., Reardon, B., Gokhale, P. C., Paweletz, C. P., Awad, M. M., Van Allen, E. M., Lako, A., Wang, X. T., Chen, B., Hong, F., Sholl, L. M., Tolstorukov, M. Y., Pfaff, K., Jänne, P. A., Gjini, E., Edwards, R., Rodig, S., Reinherz, E. L., Oser, M. G. & Barbie, D. A., Aug 2021, In: Cancer Discovery. 11, 8, p. 1952-1969 18 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    117 Scopus citations
  • Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence

    Wu, Z., Zhou, J., Zhang, X., Zhang, Z., Xie, Y., Liu, J. B., Ho, Z. V., Panda, A., Qiu, X., Cejas, P., Cañadas, I., Akarca, F. G., McFarland, J. M., Nagaraja, A. K., Goss, L. B., Kesten, N., Si, L., Lim, K., Liu, Y. & Zhang, Y. & 17 others, Baek, J. Y., Liu, Y., Patil, D. T., Katz, J. P., Hai, J., Bao, C., Stachler, M., Qi, J., Ishizuka, J. J., Nakagawa, H., Rustgi, A. K., Wong, K. K., Meyerson, M., Barbie, D. A., Brown, M., Long, H. & Bass, A. J., May 2021, In: Nature Genetics. 53, 6, p. 881-894 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    58 Scopus citations
  • 2020

    Tumor-Derived cGAMP Regulates Activation of the Vasculature

    Campisi, M., Sundararaman, S. K., Shelton, S. E., Knelson, E. H., Mahadevan, N. R., Yoshida, R., Tani, T., Ivanova, E., Cañadas, I., Osaki, T., Lee, S. W. L., Thai, T., Han, S., Piel, B. P., Gilhooley, S., Paweletz, C. P., Chiono, V., Kamm, R. D., Kitajima, S. & Barbie, D. A., Sep 4 2020, In: Frontiers in Immunology. 11, p. 2090 2090.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    40 Scopus citations
  • 2018

    3D microfluidic: Ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

    Aref, A. R., Campisi, M., Ivanova, E., Portell, A., Larios, D., Piel, B. P., Mathur, N., Zhou, C., Coakley, R. V., Bartels, A., Bowden, M., Herbert, Z., Hill, S., Gilhooley, S., Carter, J., Cañadas, I., Thai, T. C., Kitajima, S., Chiono, V. & Paweletz, C. P. & 3 others, Barbie, D. A., Kamm, R. D. & Jenkins, R. W., Sep 9 2018, In: Lab on a Chip. 18, 20, p. 3129-3143 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    190 Scopus citations
  • A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

    Jerby-Arnon, L., Shah, P., Cuoco, M. S., Rodman, C., Su, M. J., Melms, J. C., Leeson, R., Kanodia, A., Mei, S., Lin, J. R., Wang, S., Rabasha, B., Liu, D., Zhang, G., Margolais, C., Ashenberg, O., Ott, P. A., Buchbinder, E. I., Haq, R. & Hodi, F. S. & 32 others, Boland, G. M., Sullivan, R. J., Frederick, D. T., Miao, B., Moll, T., Flaherty, K. T., Herlyn, M., Jenkins, R. W., Thummalapalli, R., Kowalczyk, M. S., Cañadas, I., Schilling, B., Cartwright, A. N. R., Luoma, A. M., Malu, S., Hwu, P., Bernatchez, C., Forget, M. A., Barbie, D. A., Shalek, A. K., Tirosh, I., Sorger, P. K., Wucherpfennig, K., Van Allen, E. M., Schadendorf, D., Johnson, B. E., Rotem, A., Rozenblatt-Rosen, O., Garraway, L. A., Yoon, C. H., Izar, B. & Regev, A., Nov 1 2018, In: Cell. 175, 4, p. 984-997.e24

    Research output: Contribution to journalArticlepeer-review

    Open Access
    849 Scopus citations
  • Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

    Jenkins, R. W., Aref, A. R., Lizotte, P. H., Ivanova, E., Stinson, S., Zhou, C. W., Bowden, M., Deng, J., Liu, H., Miao, D., He, M. X., Walker, W., Zhang, G., Tian, T., Cheng, C., Wei, Z., Palakurthi, S., Bittinger, M., Vitzthum, H. & Kim, J. W. & 64 others, Merlino, A., Quinn, M., Venkataramani, C., Kaplan, J. A., Portell, A., Gokhale, P. C., Phillips, B., Smart, A., Rotem, A., Jones, R. E., Keogh, L., Anguiano, M., Stapleton, L., Jia, Z., Barzily-Rokni, M., Cañadas, I., Thai, T. C., Hammond, M. R., Vlahos, R., Wang, E. S., Zhang, H., Li, S., Hanna, G. J., Huang, W., Hoang, M. P., Piris, A., Eliane, J.-P., Stemmer-Rachamimov, A. O., Cameron, L., Su, M.-J., Shah, P., Izar, B., Thakuria, M., LeBoeuf, N. R., Rabinowits, G., Gunda, V., Parangi, S., Cleary, J. M., Miller, B. C., Kitajima, S., Thummalapalli, R., Miao, B., Barbie, T. U., Sivathanu, V., Wong, J., Richards, W. G., Bueno, R., Yoon, C. H., Miret, J., Herlyn, M., Garraway, L. A., Van Allen, E. M., Freeman, G. J., Kirschmeier, P. T., Lorch, J. H., Ott, P. A., Hodi, F. S., Flaherty, K. T., Kamm, R. D., Boland, G. M., Wong, K.-K., Dornan, D., Paweletz, C. P. & Barbie, D. A., Jan 2018, In: Cancer Discovery. 8, 2, p. 196-215 20 p.

    Research output: Contribution to journalArticlepeer-review

    404 Scopus citations
  • Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses

    Canadas, I., Thummalapalli, R., Kim, J. W., Kitajima, S., Jenkins, R. W., Christensen, C. L., Campisi, M., Kuang, Y., Zhang, Y., Gjini, E., Zhang, G., Tian, T., Sen, D. R., Miao, D., Imamura, Y., Thai, T. C., Piel, B., Terai, H., Aref, A. R. & Hagan, T. & 18 others, Koyama, S., Watanabe, M., Baba, H., Adeni, A. E., Lydon, C. A., Tamayo, P., Wei, Z., Herlyn, M., Barbie, T. U., Uppaluri, R., Sholl, L. M., Sicinska, E., Sands, J., Rodig, S., Wong, K. K., Paweletz, C. P., Watanabe, H. & Barbie, D. A., Jul 2018, In: Nature Medicine. 24, 8, p. 1143-1150 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    212 Scopus citations
  • 2017

    Organoid culture: Applications in development and cancer

    Cañadas, I. & Barbie, D. A., 2017, In: Cancer Drug Discovery and Development. 0, p. 41-54 14 p.

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations
  • 2016

    Autophagy inhibition dysregulates TBK1 signaling and promotes pancreatic inflammation

    Yang, S., Imamura, Y., Jenkins, R. W., Canadas, I., Kitajima, S., Aref, A., Brannon, A., Oki, E., Castoreno, A., Zhu, Z., Thai, T., Reibel, J., Qian, Z., Ogino, S., Kwong, K., Baba, H., Kimmelman, A. C., Magliano, M. P. D. & Barbie, D. A., Jun 2016, In: Cancer Immunology Research. 4, 6, p. 520-530 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    83 Scopus citations
  • The first-in-class anti-EGFR antibody mixture Sym004 overcomes cetuximab resistance mediated by EGFR extracellular domain mutations in colorectal cancer

    Sánchez-Martín, F. J., Bellosillo, B., Gelabert-Baldrich, M., Dalmases, A., Cañadas, I., Vidal, J., Martinez, A., Argilés, G., Siravegna, G., Arena, S., Koefoed, K., Visa, L., Arpí, O., Horak, I. D., Iglesias, M., Stroh, C., Kragh, M., Rovira, A., Albanell, J. & Tabernero, J. & 2 others, Bardelli, A. & Montagut, C., Jul 1 2016, In: Clinical Cancer Research. 22, 13, p. 3260-3267 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    65 Scopus citations
  • 2015

    Angiopoietin-2 is a negative prognostic marker in small cell lung cancer

    Canadas, I., Taus, Á., Villanueva, X., Arpí, O., Pijuan, L., Rodríguez, Y., Menéndez, S., Mojal, S., Rojo, F., Albanell, J., Rovira, A. & Arriola, E., Nov 2015, In: Lung Cancer. 90, 2, p. 302-306 5 p.

    Research output: Contribution to journalArticlepeer-review

    19 Scopus citations
  • Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer

    Arena, S., Bellosillo, B., Siravegna, G., Martínez, A., Cañadas, I., Lazzari, L., Ferruz, N., Russo, M., Misale, S., González, I., Iglesias, M., Gavilan, E., Corti, G., Hobor, S., Crisafulli, G., Salido, M., Sánchez, J., Dalmases, A., Bellmunt, J. & De Fabritiis, G. & 5 others, Rovira, A., Di Nicolantonio, F., Albanell, J., Bardelli, A. & Montagut, C., May 1 2015, In: Clinical Cancer Research. 21, 9, p. 2157-2166 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    231 Scopus citations
  • MET expression and copy number heterogeneity in nonsquamous non-small cell lung cancer (nsNSCLC)

    Casadevall, D., Gimeno, J., Clavé, S., Taus, Á., Pijuan, L., Arumí, M., Lorenzo, M., Menéndez, S., Cañadas, I., Albanell, J., Serrano, S., Espinet, B., Salido, M. & Arriola, E., 2015, In: Oncotarget. 6, 18, p. 16215-16226 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    57 Scopus citations
  • 2014

    High circulating hepatocyte growth factor levels associate with epithelial to mesenchymal transition and poor outcome in small cell lung cancer patients

    Cañadas, I., Taus, Á., González, I., Villanueva, X., Gimeno, J., Pijuan, L., Dómine, M., Sánchez-Font, A., Vollmer, I., Menéndez, S., Mojal, S., Arpí, O., Rojo, F., Rovira, A., Albanell, J. & Arriola, E., 2014, In: Oncotarget. 5, 14, p. 5246-5256 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    37 Scopus citations
  • Targeting epithelial-to-mesenchymal transition with met inhibitors reverts chemoresistance in small cell lung cancer

    Canadas, I., Rojo, F., Taus, A., Arpi, O., Uria, M. A., Pijuan, L., Menendez, S., Zazo, S., Domine, M., Salido, M., Mojal, S., De Herreros, A. G., Rovira, A., Albanell, J. & Arriola, E., 2014, In: Clinical Cancer Research. 20, 4, p. 938-950 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    114 Scopus citations
  • 2011

    Increased ALK gene copy number and amplification are frequent in non-small cell lung cancer

    Salido, M., Pijuan, L., Martínez-Avilés, L., Galván, A. B., Cañadas, I., Rovira, A., Zanui, M., Martínez, A., Longarón, R., Sole, F., Serrano, S., Bellosillo, B., Wynes, M. W., Albanell, J., Hirsch, F. R. & Arriola, E., Jan 2011, In: Journal of Thoracic Oncology. 6, 1, p. 21-27 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    144 Scopus citations
  • 2009

    Cytogenetic characterization of NCI-H69 and NCI-H69AR small cell lung cancer cell lines by spectral karyotyping

    Salido, M., Arriola, E., Carracedo, A., Cañadas, I., Rovira, A., Espinet, B., Rojo, F., Arumi, M., Serrano, S., Albanell, J. & Sole, F., Jun 2009, In: Cancer Genetics and Cytogenetics. 191, 2, p. 97-101 5 p.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
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