Personal profile
Research interests
Targeting innate immunity in lung cancer
- Study of tumor immunity and the tumor microenvironment in lung cancer
- Deciphering mechanisms of Endogenous Retroviruses (ERV) silencing and reactivation at the epigenetic level.
- Study of cytosolic nucleic acid-sensing pathways in the context of innate and adaptive antitumor immunity.
- Development of novel functional ex vivo organotypic 3D culture platforms to identify and characterize mechanisms of response and resistance to immunotherapy using murine and patient derived tumor samples.
Lab Overview
The Cañadas Lab studies tumor immunity and the tumor microenvironment in lung cancer with the ultimate goal of identifying new therapeutic opportunities to improve patient health.
We are primarily interested in delineating mechanisms of tumor resistance to immunotherapy, and in leveraging innate immune signaling pathways to break therapy resistance and restore immunogenicity.
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Collaborations and top research areas from the last five years
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EGFR-mutant transformed small cell lung cancer harbors intratumoral heterogeneity targetable with MEK inhibitor combination therapy
Ogino, A., Vajdi, A., Mu, X. J., Mahadevan, N. R., Ngo, K., Booker, M. A., Cejas, P., Okoro, J. J., Xu, M., Springer, B. F., Eschle, B. K., Messier, C. M., Wang, S., Syamala, S., Tamen, R. M., Adeni, A. E., Chambers, E. S., Canadas, I., Thai, T. & Christensen, C. L. & 12 others, , Jan 23 2026, In: JCI insight. 11, 2Research output: Contribution to journal › Article › peer-review
Open Access -
Autophagy in cancer development, immune evasion, and drug resistance
Niu, X., You, Q., Hou, K., Tian, Y., Wei, P., Zhu, Y., Gao, B., Ashrafizadeh, M., Aref, A. R., Kalbasi, A., Cañadas, I., Sethi, G., Tergaonkar, V., Wang, L., Lin, Y., Kang, D. & Klionsky, D. J., Jan 2025, In: Drug Resistance Updates. 78, 101170.Research output: Contribution to journal › Review article › peer-review
Open Access142 Scopus citations -
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis
Murayama, T. & Cañadas, I., Apr 1 2025, In: Cancer Discovery. 15, 4, p. 670-672 3 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression
Cañadas, I., Murayama, T. & Galluzzi, L., Aug 2025, In: Trends in Cancer. 11, 8, p. 716-718 3 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
RNA sensing induced by chromosome missegregation augments anti-tumor immunity
Sasaki, N., Homme, M., Murayama, T., Osaki, T., Tenma, T., An, T., Takegami, Y., Tani, T., Gedeon, P. C., Kobayashi, Y., Cañadas, I., Barbie, D. A., Yao, R. & Kitajima, S., Feb 20 2025, In: Molecular Cell. 85, 4, p. 770-786.e7Research output: Contribution to journal › Article › peer-review
13 Scopus citations
Press/Media
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New Necroptosis Study Findings Have Been Reported from Fox Chase Cancer Center (Abstract 3102: Spliceosome perturbation enhances immunotherapy in SCLC by triggering ZBP1-driven necroptosis in cancer-associated fibroblasts)
Balachandran, S., Canadas, I. & Zhou, Y.
04/22/26
1 item of Media coverage
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Spliceosome Inhibitor Therapy Shows Promise in Turning 'Cold' Tumors 'Hot,' Boosting Immunotherapy
11/25/25
1 item of Media coverage
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Fox Chase Cancer Center Researchers Find Gene That Triggers Immune Response in Treatment-Resistant Small-Cell Lung Cancer
10/11/24
1 item of Media coverage
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