Research output per year
Research output per year
Personal profile
Research interests
Targeting innate immunity in lung cancer
- Study of tumor immunity and the tumor microenvironment in lung cancer
- Deciphering mechanisms of Endogenous Retroviruses (ERV) silencing and reactivation at the epigenetic level.
- Study of cytosolic nucleic acid-sensing pathways in the context of innate and adaptive antitumor immunity.
- Development of novel functional ex vivo organotypic 3D culture platforms to identify and characterize mechanisms of response and resistance to immunotherapy using murine and patient derived tumor samples.
Lab Overview
The Cañadas Lab studies tumor immunity and the tumor microenvironment in lung cancer with the ultimate goal of identifying new therapeutic opportunities to improve patient health.
We are primarily interested in delineating mechanisms of tumor resistance to immunotherapy, and in leveraging innate immune signaling pathways to break therapy resistance and restore immunogenicity.
URL
Fingerprint
Dive into the research topics where Israel Canadas is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Autophagy in cancer development, immune evasion, and drug resistance
Niu, X., You, Q., Hou, K., Tian, Y., Wei, P., Zhu, Y., Gao, B., Ashrafizadeh, M., Aref, A. R., Kalbasi, A., Cañadas, I., Sethi, G., Tergaonkar, V., Wang, L., Lin, Y., Kang, D. & Klionsky, D. J., Jan 2025, In: Drug Resistance Updates. 78, 101170.Research output: Contribution to journal › Review article › peer-review
59 Scopus citations -
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis
Murayama, T. & Cañadas, I., Apr 1 2025, In: Cancer Discovery. 15, 4, p. 670-672 3 p.Research output: Contribution to journal › Article › peer-review
-
mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression
Cañadas, I., Murayama, T. & Galluzzi, L., Aug 2025, In: Trends in Cancer. 11, 8, p. 716-718 3 p.Research output: Contribution to journal › Article › peer-review
-
RNA sensing induced by chromosome missegregation augments anti-tumor immunity
Sasaki, N., Homme, M., Murayama, T., Osaki, T., Tenma, T., An, T., Takegami, Y., Tani, T., Gedeon, P. C., Kobayashi, Y., Cañadas, I., Barbie, D. A., Yao, R. & Kitajima, S., Feb 20 2025, In: Molecular Cell. 85, 4, p. 770-786.e7Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Spliceosome inhibition induces Z-RNA and ZBP1-driven cell death in small cell lung cancer
Jiang, X., Ma, X., Zhou, Y., Liu, X., Zhang, T., Kim, W., Balachandran, S. & Cañadas, I., Oct 28 2025, In: Cell Reports. 44, 10, p. 116384 116384.Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
-
Fox Chase Cancer Center Researchers Find Gene That Triggers Immune Response in Treatment-Resistant Small-Cell Lung Cancer
10/11/24
1 item of Media coverage
Press/Media
-
Fox Chase Cancer Center Researcher Reports on Findings in Lung Cancer (Targeting DHX9 triggers tumor-intrinsic interferon response and replication stress in Small Cell Lung Cancer)
Chen, L., Yang, Y., Canadas, I., Campbell, K. S., Zhou, Y., Balachandran, S. & Cai, K. Q.
01/23/24
1 item of Media coverage
Press/Media
-
DXH9 Depletion May Expose Small Cell Lung Cancer Tumors to Immune System Attack
01/17/24
1 item of Media coverage
Press/Media
-
Fox Chase Cancer Center: Study Finds Novel Mechanism for Making Small Cell Lung Cancer Tumors Vulnerable to Attack by Immune System
01/13/24
1 item of Media coverage
Press/Media