Personal profile
Personal profile
Treatment Philosophy
I chose to stay at Fox Chase as an attending physician for the love of the institutional environment and the great patients I am so privileged to treat. I love my work for the great team spirit cultivated among my colleagues, physicians and nurses. I am extremely grateful to the fact that patients are at the center of everybody’s attention. It is easy for me to do my job in such an atmosphere of concern and indefatigable compassion.
Fox Chase also offers me an opportunity to work both in the clinic and in the lab, where I am studying cancer biology with the goal to design better treatment options for the patients. In my field of gastrointestinal malignancies, I am convinced that the treatment choices for each individual cancer patient will soon be defined by the molecular makeup of their cancer cells. This knowledge can help us match the treatment strategies with the biology of individual patient’s tumors. I am interested to translate the knowledge about cancer available in the lab to the clinic by conducting hypothesis-driven clinical trials.
I am deeply convinced that the best way to help our patients is to push the boundaries by doing clinical and basic research.
Research interests
Cancer Metabolism and signaling
- The central role for sterol metabolism in regulation of cell growth and signaling
- Pancreatic cancer biology and "smart drugs" for treatment of pancreatic cancer
- Translating therapeutic concepts to the clinic using the platform of patient-derived avatar models and genetically engineered pancreatic cancer models
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Collaborations and top research areas from the last five years
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Breaking barriers: Smart vaccine platforms for cancer immunomodulation
Gomari, M. M., Ghantabpour, T., Pourgholam, N., Rostami, N., Hatfield, S. M., Namazifar, F., Abkhiz, S., Eslami, S. S., Ramezanpour, M., Darestanifarahani, M., Astsaturov, I. & Bencherif, S. A., May 2025, In: Cancer Communications. 45, 5, p. 529-571 43 p.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations -
Olaparib in Patients With Solid Tumors With BRCA1/2 Alterations: Results From The Targeted Agent and Profiling Utilization Registry (TAPUR) Study
Al Baghdadi, T., Rothe, M., Mangat, P. K., Garrett-Mayer, E., Crysler, O. V., Mileham, K. F., Farrington, L. C., Adesunloye, B., Dublis, S. A., Astsaturov, I., Calfa, C. J., Bleeker, J., Khalil, M., Thota, R., Cannon, T. L., Alese, O. B., Gold, P. J., Hafez, N., Baron, A. D. & Meric-Bernstam, F. & 9 others, , Oct 2025, In: JCO Precision Oncology. 9, p. e2500649 26 p., e2500649.Research output: Contribution to journal › Article › peer-review
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Overeating: A Conundrum of Lipid Metabolism and Inflammation in Obesity and Cancer
Surumbayeva, A., Saiman, Y. & Astsaturov, I., Oct 2025, In: Journal of Cellular Physiology. 240, 10, p. e70104 e70104.Research output: Contribution to journal › Review article › peer-review
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Racial/Ethnic Differences and Effects of Clinical/Socioeconomic Factors on Time from Diagnosis to Treatment in Pancreatic Cancer
Sridharan, A., Dotan, E., Dorta, M., Vemula, N., Handorf, E., Deng, M., Renning, A., Sorice, K., Laderman, L., Whittington, K., Cukierman, E., Astsaturov, I., Vijayvergia, N., Meyer, J. E., Reddy, S. S. & Lynch, S. M., Feb 15 2025, In: Journal of Gastrointestinal Cancer. 56, 1, p. 67 67.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Food Insecurity and Dietary Quality in African American Patients with Gastrointestinal Cancers: An Exploratory Study
Dratsky, D., McGillivray, E., Mittal, J., Handorf, E. A., Berardi, G., Astsaturov, I., Hall, M. J., Yeh, M. C., Jain, R. & Fang, C. Y., Sep 2024, In: Nutrients. 16, 18, 3057.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Prizes
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The Paul F. Engstrom Professorship in Oncology
Astsaturov, I. (Recipient), 2023
Prize: Other distinction
Press/Media
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Studies from Fox Chase Cancer Center Update Current Data on Pancreatic Cancer (Racial/Ethnic Differences and Effects of Clinical/Socioeconomic Factors on Time from Diagnosis to Treatment in Pancreatic Cancer)
Vijayvergia, N., Reddy, S. S., Meyer, J. E., Cukierman, E. & Astsaturov, I.
03/16/26
1 item of Media coverage
Press/Media
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Paul Engstrom: Fox Chase Cancer Prevention Pioneer Dies at 89
Clapper, M., Daly, M. & Astsaturov, I.
01/10/26
1 item of Media coverage
Press/Media
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Philadelphia Magazine Names 142 Fox Chase Cancer Center Physicians 'Top Doctors'
Mantia-Smaldone, G. M., Vijayvergia, N., Borghaei, H., Weiss, S. E., Kumar, R., Khanal, R., Frosch, Z. A., Flieder, D. B., Chen, D. Y., Plimack, E. R., Manley, C. J., Nejati, R. M., Ehya, H., Kutikov, A., Sherry, D. R., Hallman, M. A., Uzzo, R. G., Patel, S. A., Daly, M., Viterbo, R., Curcillo, P. G., Bleicher, R., Edelman, M., Greco, S. H., Miyamoto, C. T., von Mehren, M., Chwistek, M., Galloway, T. J., Jain, A., Meyer, J. E., Castellanos, J. A., Farma, J. M., Weinberg, D. S., Friedberg, J., Wasik, M. A., Zibelman, M. R., Wang, Y. L., Astsaturov, I., Olszanski, A. J., Simhan, J., Friedlander, J. I., Cohn, J., Sterious, S., Wei, S., Giri, A. P., Berman, A. T., Loren, D. E., McCue, P. A., Abdelmessieh, P., Ahmad, D., Messmer, M., Ghiraldi, E. M., Horwitz, E. M., Correa, A. F., Yu, J. Q., Smaldone, M. C., Villano, A. M., Aphale, A., McShane, M. M., Kumar, S. S., Walchak, A., Wookey, V. B., Wong, J. K., Nakhoda, S. K., Bauman, J., Williams, A. D., Hall, M. J., Fung, H. C., Reddy, S. S. & Geynisman, D.
04/22/25
1 item of Media coverage
Press/Media