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Hossein Borghaei, DO, MS

Professor, The Gloria and Edmund M. Dunn Chair in Thoracic Surgical Oncology, Chief, Division of Thoracic Medical Oncology, Co-Director, Immune Monitoring Facility

1997 …2026

Research activity per year

Personal profile

Personal profile

Treatment Philosophy

I decided to stay at Fox Chase Cancer Center after completing my fellowship here because I believe in the mission of this center. I believe that Fox Chase provides my patients with an environment that is not only patient friendly but also a place that great care can be delivered. I can offer many of the top clinical trials to my patients if needed and help advance the field of lung cancer therapy. With the dedicated nurses, social workers and support staff at Fox Chase I have the right team in place to help me care for my patients.

I also believe that we treat more than just a disease. I consider the patient as a whole, an individual with a disease and not just the disease.  I believe in engaging patients and their families in their care to the extent that my patients allow it. I believe in a team approach to the care of patients with lung cancer and along with my colleagues in the thoracic division we can deliver the best level of care that is possible.

Research interests

Monoclonal Antibody, Targeted Therapy, Immunotherapy, Cancer Vaccine

My laboratory concentrates on the development of new cancer treatments with an emphasis on the use of immunotherapy and monoclonal antibodies. We are capable of making new monoclonal antibodies against various cancer related targets and have recently received a patent for one such antibody. In collaboration with a number of other scientists at Fox Chase and as a result of laboratory based studies conducted here, I have developed clinical trials that are ongoing for treatment of patients with lung cancer.

My collaborations with scientists outside of Fox Chase also is an important part of what I do with the aim of bringing newer and more effective immune based treatments to the clinic. My laboratory also examines patients’ tumors to try to learn why some patients respond to specific treatment while others don’t. Discovery of new or better ways of treating cancer is an important part of my activities here.

In addition to laboratory based investigations, I am active in clinical trials. My goal is to offer my patients some of the best options that are available. I believe that clinical trials, when offered appropriately, can not only help us develop the next best treatment options but also allow my patients access to potentially new and promising drugs.

In addition I am actively involved in lung cancer screening and research involving potential preventative measures with the hope of detecting lung cancer early and preventing recurrences of this disease.

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  • An AI Approach to Differentiating Lung Squamous Cell Carcinoma From Metastases of Other Origins

    Evans, M. G., Ribeiro, J. R., Maney, T., Helmstetter, A., Johnson, J., Karnezis, A. N., Bales, C., Sledge, G. W., Spetzler, D., Vanderwalde, A., Oberley, M., Halmos, B., Borghaei, H., Abdulla, F., Bryant, D., Hirsch, F. R. & Ghani, H., Mar 18 2026, In: Jama Network Open. 9, 3, p. e260908 e260908.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Bridging evidence and practice: international multidisciplinary consensus on non-metastatic NSCLC

    Meyer, M.-L., Peters, S., Borghaei, H., Cascone, T., Dacic, S., Faivre-Finn, C., Leighl, N., Paz-Ares, L., Aerts, J., Aggarwal, C., Ahn, M.-J., Arcila, M. E., Ardizzoni, A., Arrieta, O., Awad, M. M., Bar, J., Barlesi, F., Bazhenova, L., Besse, B. & Chaft, J. & 70 others, Cho, B. C., Curioni Fontecedro, A., DE Ruysscher, D., Dingemans, A.-M., Dziadziuszko, R., Felip, E., Forde, P., Gandara, D. R., Garassino, M. C., Garcia Campelo, R., Garrido Lopez, P., Gautschi, O., Girard, N., Goto, Y., Gray, J., Hendriks, L., Hirsch, F., Hui, R., Janne, P. A., Kerr, K., Khorshid, O., Pechoux, C. L. E., Leal, T., Lin, J. J., Linardou, H., Liu, S., Mahrous, M., Malapelle, U., Mercadante, E., Mitsudomi, T., Mok, T., Mountzios, G., Naidoo, J., Normanno, N., Novello, S., Oliveira, J., Pappagallo, G., Perrone, G., Pérol, M., Raez, L. E., Ramella, S., Rami-Porta, R., Reckamp, K., Reguart Aransay, N., Remon Masip, J., Ricardi, U., Ricciuti, B., Rodriguez-Abreu, D., Rotow, J. K., Santos, E. S., Schalper, K., Senan, S., Seto, T., Skoulidis, F., Smit, E. F., Soares, M., Solli, P., Solomon, B., Soo, R. A., Stahel, R., Stiles, B. M., VAN Schil, P., Veronesi, G., Wistuba, I. I., Wolf, J., Wu, Y.-L., Zer, A., Rolfo, C., Landi, L. & Cappuzzo, F., Jul 30 2026, (E-pub ahead of print) In: Journal of Thoracic Oncology. p. 104111

    Research output: Contribution to journalArticlepeer-review

  • Combination AURKA and WEE1 inhibition exhibits efficacy in EGFR or pan-ERBB inhibitor resistant head and neck squamous cell carcinoma

    Silva, F. N., Lee, J. W., Nguyen, T. T., Goeckel, F. M., Bagnyukova, T., Borghaei, H., Golemis, E. A. & Burtness, B. A., Jul 30 2026, (E-pub ahead of print) In: Cancer Research Communications.

    Research output: Contribution to journalArticlepeer-review

  • Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab-Based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer

    Borghaei, H., Balli, D., Paz-Ares, L. G., Reck, M., Lu, S., Ramalingam, S. S., Brahmer, J. R., John, T., Carbone, D. P., Ciuleanu, T.-E., Schenker, M., Cobo, M., Zurawski, B., Pluzanski, A., Lee, J.-S., Agrawal, S., Spires, T., Neely, J., Ip, V. & Eccles, L. J. & 7 others, Chang, H., Szustakowski, J. D., Bhatia, S., Yadav, A., Eddy, N., Geese, W. J. & O'Byrne, K. J., Jun 26 2026, (E-pub ahead of print) In: Clinical Cancer Research. p. OF1-OF14

    Research output: Contribution to journalArticlepeer-review

  • Fast Real-Time Assessment of Combination Therapies in Immuno-ONcology in patients with advanced non-small-cell lung cancer (FRACTION-Lung)

    He, K., Forde, P. M., Govindan, R., Santoro, A., Gettinger, S., Borghaei, H., Spira, A., Chu, Q., Zinner, R., Schoenfeld, A. J., Camidge, D. R., Spigel, D. R., Gurpide, A., Juergens, R. A., Laurie, S. A., Cerra, M., Spires, T., Greenawalt, D. M., Rapoport, I. & Gainor, J. F., Mar 2026, In: ESMO Open. 11, 3, p. 106078 106078.

    Research output: Contribution to journalArticlepeer-review

    Open Access